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MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBCNARA Subscribed
Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activation of the MAPK signaling pathway decreases the levels of tumor-infiltrating lymphocytes in triple-negative breast cancer (TNBC) and is associated with worse survival. Here, we investigated...
Controversy and consensus: common ground and best practices for life cycle assessment of emerging technologiesNARA Subscribed
Public and private interest in life cycle assessment (LCA) has grown as environmental disclosure norms tighten, driving demand for decision-relevant assessment early in technological development cycles. Early-stage LCA has the potential to guide design choices, steer innovation, and mitigate lock-in of adverse environmental impacts. However, many aspects of early-stage LCA practice remain unsettled. We convened experts in a se...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed