Purpose The Ebro Basin is one of the most industrialised regions of the Iberian Peninsula, yet its long-term legacy of metal contamination remains poorly constrained due to the scarcity of continuous sedimentary archives in semi-arid environments. This study reconstructs the history of mercury (Hg) and lead (Pb) pollution in the Ebro Basin using Lake Chiprana, the only permanent hypersaline lake providing a continuous, high-re...

On recently deglaciated terrain, soil instability can be a physical barrier limiting seedling establishment. Here we used a space-for-time approach to study the role of biological soil crust (biocrust) as soil surface stabilizer and facilitator of ecological succession along a glacier forefield chronosequence at the retreating Conejeras glacier in the Tropical Andes. We used the point-intercept method to estimate surface cover...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...

Olive oil is the main source of lipid energy in the Mediterranean diet and there is strong evidence of its health benefits. The effect of extra virgin olive oil (EVOO) in the form of a preparation of spreadable virgin olive oil (S-VO) on the progression of atheroma plaques was investigated in Apoe -deficient mice, a model of accelerated atherosclerosis. Methods: Two isocaloric Western purified diets containing 20% fat, either...