Purpose The Ebro Basin is one of the most industrialised regions of the Iberian Peninsula, yet its long-term legacy of metal contamination remains poorly constrained due to the scarcity of continuous sedimentary archives in semi-arid environments. This study reconstructs the history of mercury (Hg) and lead (Pb) pollution in the Ebro Basin using Lake Chiprana, the only permanent hypersaline lake providing a continuous, high-re...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...