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The interplay between systolic and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) progression is unclear. First-phase ejection fraction (EF1), a sensitive marker of early systolic function, aids in assessing systolic-diastolic relationships in human hypertension and aortic stenosis. This study examines temporal changes in these relationships in mouse models of HFpEF and elevated afterload. Mous...
The P2X7 receptor (or P2X7) is an ATP-gated ion channel with important roles in the immune and other body systems. Much has been garnered about P2X7 using the first published anti-human P2X7 monoclonal antibody (mAb) (clone L4). This mAb can be used to impair P2X7 channel and pore activity and events downstream of P2X7 activation in vitro and in vivo. Immunolabelling with this mAb has been used in flow and mass cytometry, conf...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
A substantial literature has developed on facultative endosymbionts of insects, often portrayed as having large effects on their hosts, ranging from mutualistic to parasitic. The aphid endosymbiont Regiella insecticola occurs naturally in Myzus persicae and has potential biocontrol applications. Here, we examined the effects of native Regiella in two clones of M. persicae from Australia collected two decades apart, to assess w...
Global warming intensifies regional precipitation imbalances that disrupt cropland nitrogen cycling and threaten food security. Here, we show that global croplands respond asymmetrically to future precipitation change. Under a middle of the road scenario for 2050, 78% of croplands are projected to become wetter, increasing yields by 15% but raising nitrogen losses by 45%. The remaining 22% that become drier would experience a...
The plant ontology of cell typesNARA Subscribed
AI misuse of retracted literature: A comparative study of ChatGPT4o, deepseek, and grok 3 in stem cell researchNARA Subscribed
DeepSeek and Grok 3 appear as strong competitors to AI models, particularly the widely accepted model, ChatGPT. The accuracy of the utilization of data in retracted scientific articles has proven to be a significant challenge for AI as an assistant in scientific research. It is critical to understand whether and how three AI models handle information from retracted articles when they answer scientific questions. We collected r...