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Correlation between DNA methylation and transcriptomic changes in golden Asian sea bass ( Lates calcarifer ): An integrated approachNARA Subscribed
Lates calcarifer , commonly known as barramundi perch, Asian sea bass or barramundi, is a significant aquaculture species across the Indo‐Pacific. Barramundi typically exhibit a silver to bronze wild‐type (WT) skin colour, with occasional golden (xanthic) variants of commercial interest. Although previous studies have identified gene expression differences between golden and WT variants, the genetic mechanism driving golden co...
Fecal Microbiome Varies With Social Group, Age and Bovine Tuberculosis Infection in the European Badger ( Meles meles )NARA Subscribed
Host‐associated microbes are key components of animal health and physiology, with particular importance for determining responses to pathogen infection. The gut microbiota is highly variable at the individual level, being shaped by a multitude of factors including diet, social behaviour, and age. Yet the relative influence of these traits on microbiota composition, and the consequences of this variation for host responses to p...
Plants employ multiple strategies to adapt to their growth environment. Characterizing key dimensions in plant trait space is important for understanding functional diversity within ecosystems. Leaf and root functional traits have been studied in the context of resource economics, but whether they covary, and through which mechanisms, is still debated. We investigated this in subtropical forests by sampling root and leaf trait...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Marine species with high fecundity and larvae with long-distance dispersal potential can have complex population genetic patterns. Characterizing population structure in these species is important for understanding their ecology and life history and designing management strategies. The eastern oyster (Crassostrea virginica) is both ecologically and economically important but has experienced recent population declines. Characte...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330NARA Subscribed
The proteostatic decline in Alzheimer’s disease is well established, and improvement in proteostasis could potentially delay cognitive impairment. One emerging entry point to modulate proteostasis is the regulation of nucleo-cytoplasmic partitioning of proteins across the nuclear pore via karyopherins. The nuclear exportin XPO1 is a key regulator of proteostasis by driving the assembly of ribosomes and by modulating the proces...
Mapping area of habitat for inland wetland speciesNARA Subscribed
Area of habitat (AOH) maps provide a high‐resolution representation of the habitat available in a species’ range and can support conservation policy and planning processes. However, until recently, there was insufficient knowledge on the distribution of inland wetlands and freshwater biodiversity to develop AOH mapping methods specifically tailored to inland wetlands. We used a combined empirical and thematic approach to trans...