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Physics-based 3D ground motion simulations of the 1703 L’Aquila earthquake: from historical reconstruction to seismic scenariosNARA Subscribed
The city of L’Aquila (central Italy) and its surrounding villages have been struck several times throughout history by strong earthquakes, most recently by the $$M_w$$ M w 6.1 event of April 6, 2009. Previously, on February 2, 1703, L’Aquila was partially destroyed by a $$M_w$$ M w 6.7 earthquake, which has remained in the city’s collective memory as the Grande Terremoto (“Big Earthquake”). In this paper, we present a physics-...
Multimorbidity as a predictor of mortality in companion dogsNARA Subscribed
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studiesNARA Subscribed
Although aging is a universal event, some individuals are able to achieve extreme longevity. The Long-Life Family Study (LLFS) enrolls participants from families enriched with long-lived individuals, serves as a valuable dataset for studying ageing phenotypes and identify potential intervention targets. We analyzed the association between age at blood draw and 16,284 RNAseq-based blood transcriptomic data from 2,167 LLFS parti...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Does your job really matter? Job-specific cancer incidence among a cohort coal mine workers in Queensland, AustraliaNARA Subscribed
Purpose Globally, coal production exposes millions of workers to coal mine dust. This study aimed to measure overall and site specific cancer incidence among coal mine workers (CMW) who performed different types of work. Methods A retrospective cohort of CMW in Queensland, Australia, was assembled using health assessment records from 1992. CMW were grouped by job type and then into Work Categories and linked to the Australian...
A Detailed Characterization of the Whistle Repertoire of Fraser's Dolphins ( Lagenodelphis hosei ) From the Lesser AntillesNARA Subscribed
Fraser's dolphin ( Lagenodelphis hosei ) remains poorly studied due to its elusive behavior, rarity, and preference for deep offshore habitats. While dolphins use frequency‐modulated whistles for communication, detailed acoustic descriptions exist for only a few species. This study provides the first comprehensive characterization of Fraser's dolphin whistle acoustic structure and repertoire, based on recordings from eight gro...