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The interplay between systolic and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) progression is unclear. First-phase ejection fraction (EF1), a sensitive marker of early systolic function, aids in assessing systolic-diastolic relationships in human hypertension and aortic stenosis. This study examines temporal changes in these relationships in mouse models of HFpEF and elevated afterload. Mous...
Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorderNARA Subscribed
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent and heritable of neurodevelopmental disorders. To characterize the genetic variants contributing to this heritability, we studied families with members affected by ADHD. Genome-wide array data were obtained on two cohorts: NHGRI Family Cohort (359 nuclear families,1538 individuals) and NCR Family Cohort (25 multigenerational and 132 nuclear families,...
Understanding movement and habitat use patterns of co-occurring predatory fishes is crucial for effective conservation and management of estuarine ecosystems, where dynamic seasonal shifts and species interactions play crucial roles in shaping community structure. Using acoustic telemetry and network analysis, we compared the movements of alligator gar ( Atractosteus spatula , n = 13), bull sharks ( Carcharhinus leucas , n = 1...
In Situ Evidence for Quantitative Nitrogen Fixation in a Temperate Perennial Grass EcosystemNARA Subscribed
Biological nitrogen (N) fixation is an important terrestrial ecosystem N input that occurs in both symbiotic and non-symbiotic associations with plants. Non-symbiotic nitrogen fixation (NSNF) has been documented in many places, including soils, but the magnitude of its inputs, along with drivers of NSNF rates, remains uncertain due to methodological challenges. We measured NSNF by applying a 15 N 2 tracer to field mesocosms th...
Multiple Strains of Trichomonas gallinae are Widespread in Reservoir Hosts and Environmental Resources in UK FarmlandNARA Subscribed
Understanding transmission routes of parasites and pathogens is critical for the development of control measures and mitigation of impacts on host populations. Trichomonas gallinae is a widespread parasite in columbids worldwide, and has emerged as a lethal disease in passerines, particularly finches. The postulated transmission route from columbids to passerines via spillover at shared resources has not yet been empirically t...
Remote Spectral Detection of Canopy Functional Dimensions Varying Within and Across Forest TypesNARA Subscribed
Global trait axes reveal overarching dimensions of plant functional variation. However, how these dimensions are spatially organized within and across forest types remains unclear. We combined drone‐based full‐range imaging spectroscopy with crown‐level measurements of 16 physiological, morphological and biochemical traits across temperate, subtropical and tropical forests in China to enable spatially‐explicit trait mapping. T...
It is well known that heat recovery of high-temperature aquifer thermal energy storage (HT-ATES) systems is negatively impacted by buoyancy-driven flow of the injected hot, low-density water during storage. Density differences, however, also affect pressure head conditions within the well and therefore pressure head differences with the aquifer. Thus, it was anticipated that nonuniform flow distribution across the well screen...
Purpose Spinal deformities and motions of the spinal joints are rarely confined to a single anatomical plane. Yet diagnosis of such deformities and characterizations of their biomechanical behavior under load are often limited to two-dimensional methods of analysis. This study presented a testing methodology and visualization method to characterize the biomechanical responses of the intact and deformed lumbar spine under combi...