Developmental exposure to carbamates, organophosphates, and pyrethroids has been associated with impaired neurodevelopmental outcomes. Sex-specific differences following chronic insecticide exposure are rather common in vivo. Therefore, we assessed the chronic effects of in vitro exposure to different carbamates (carbaryl, methomyl and aldicarb), organophosphates [chlorpyrifos (CPF), chlorpyrifos-oxon (CPO), and 3,5,6,trichlor...

During landfalling tropical storms, predictions of the expected storm surge are critical for guiding evacuation and emergency response/preparedness decisions, both at regional and national levels. Forecast errors related to storm track, intensity, and size impact these predictions and, thus, should be explicitly accounted for. The Probabilistic tropical storm Surge (P-Surge) model is the established approach from the National...

In chemical risk assessment, default uncertainty factors are used to account for interspecies and interindividual differences, and differences in toxicokinetics and toxicodynamics herein. However, these default factors come with little scientific support. Therefore, our aim was to develop an in vitro method, using acetylcholinesterase (AChE) inhibition as a proof of principle, to assess both interspecies and interindividual di...