J.P. Edwards results 402
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Adaptive Variation Amid High Gene Flow Across a Broad Latitudinal Gradient in the Reef‐Building Honeycomb Worm, Sabellaria alveolataNARA Subscribed
Climate change is already altering, and will continue to reshape, the persistence and spatial structure of marine populations. Understanding metapopulation connectivity and local adaptation is therefore critical for identifying both vulnerable populations and those with adaptive resilience. We applied a seascape genomics approach to investigate connectivity patterns and adaptive responses in the honeycomb worm, Sabellaria alve...
We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...
Regional oceanographic controls on water column nitrogen fixation in northern Australian watersOA Marine
Large blooms of the diazotrophic cyanobacteria, Trichodesmium , have been reported along the north coast of Australia and are readily evident in remote sensing images. During a research cruise in November 1999, we sampled from Townsville to Broome, examined Trichodesmium population densities and their rates of carbon and N 2 fixation alongside microscopy-based cell counts of them and other cyanobacterial diazotrophs. Additiona...
The Effects of Land‐Use Dynamics on Avian Phylogenetic Diversity Across Island EcosystemsNARA Subscribed
Aim To test whether forest extent and recent forest‐cover change are associated with avian phylogenetic diversity and community‐level evolutionary value across islands. Location Seven islands spanning Borneo and Wallacea in the Malay Archipelago. Taxon Terrestrial birds. Methods We sampled 1410 sites (2010–2022). We calculated phylogenetic diversity (PD), mean phylogenetic distance (MPD), mean nearest taxon distance (MNTD) and...
Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research SocietyNARA Subscribed
Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...
Adaptive area-wide management for suppressing spruce budworm outbreaks: effectiveness of the early intervention strategyNARA Subscribed
In eastern North America, two main insecticide-based strategies are used to manage spruce budworm ( Choristoneura fumiferana ) outbreaks. The traditional ‘Foliage Protection Strategy’ (FPS) focuses on temporarily reducing defoliation and tree mortality in high-value stands, allowing outbreaks to progress naturally in surrounding areas. The ‘Early Intervention Strategy’ (EIS) is an adaptive, area-wide management approach that t...
Pathologic Description and Genetic Characterisation of Kudoa thunni From Yellowfin Tuna ( Thunnus albacares ) in the Caribbean SeaNARA Subscribed
Yellowfin tuna ( Thunnus albacares ) is a valuable recreational and commercial species in Grenada and the Caribbean region. Myxozoans, specifically the monotypic Kudoidae family within the Order Multivalvulida, are marine parasitic organisms that can negatively impact fish health and marketability. On 8 September 2023, muscle fillets from a yellowfin tuna caught off the coast of Grenada and containing numerous white nodules we...
Evaluation of siRNA-mediated knockdown of heat shock protein 16.2 in adult Acropora cervicornisOA Marine
Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult cor...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
New Guinea, the most botanically diverse island on the planet, is the location for one of the boldest conservation initiatives. The Manokwari Declaration aims to achieve 70% conservation designation for the Bird's Head Peninsula. This is 40% higher than the 2022 Global Biodiversity Framework target. However, there is a lack of species occurrence data to support evidence of where biodiversity can be best protected. To address t...
Connectivity is a multifaceted concept that has important implications for the management and conservation of marine and freshwater fishes. We developed a conceptual framework that encompasses multiple, interrelated categories of connectedness, including landscape (e.g., structural, functional) connectivity and ecological (e.g., trophic, genetic, demographic) connectivity, that together shape the flow of organisms, energy and...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Acute nutritional ketosis during early recovery from aerobic exercise does not affect skeletal muscle transcriptomic response in humansNARA Subscribed
Purpose Nutritional ketosis is purported to enhance skeletal muscle recovery and adaptation to exercise, yet precise adaptive mechanisms are unknown. We investigated the post-exercise molecular response to ketone monoesters (KME) in skeletal muscle by characterising the early transcriptomic response. Methods Following a randomised, double-blind, crossover design, recreationally active men (n = 9, age: 26 ± 5 (means ± SD) y; V̇...