HTLV-1 infection causes chronic immune activation and a prolonged asymptomatic phase, but the functional features that define early disease remain unclear. We evaluated whether spontaneous proliferation (SP) and related functional immune parameters can distinguish clinical stages across the HTLV-1 spectrum. Spontaneous and mitogen-induced lymphoproliferation (PHA, anti-CD3), measured by CFSE dilution, and in vitro cell death,...

Paramos are “insular” ecosystems confined to high-elevation zones of the Andean forests. Of the total area of paramo worldwide, 49% is found in Colombia and from these, the 18.3% within the department of Boyacá. Biogeographic and climate dynamics shape bryophyte species richness in the Neotropics. We compiled a comprehensive species list from herbarium specimens (UPTC and COL) and online databases (GBIF and Tropicos), suppleme...

Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly patients with COVID-19. For this purpose, we employed a derivation cohort with 450 SARS-CoV-2 infected and unvaccinated patients admitted to hospital wards and a validation cohort with 244 SARS-CoV-2 infected and unvaccinated patie...

Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...

This study examines the effects of environmental knowledge on pro-environmental attitudes and behavior by analyzing the relationship between general environmental knowledge (GEK), specific environmental knowledge (SEK), environmental attitudes (ENA), and public pro-environmental behavior (PPB) in two demographic groups: engineering students from universities and active engineers working in the maquiladora industry, both in Ciu...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...