Purpose The Ebro Basin is one of the most industrialised regions of the Iberian Peninsula, yet its long-term legacy of metal contamination remains poorly constrained due to the scarcity of continuous sedimentary archives in semi-arid environments. This study reconstructs the history of mercury (Hg) and lead (Pb) pollution in the Ebro Basin using Lake Chiprana, the only permanent hypersaline lake providing a continuous, high-re...

Cytotoxic edema (CE) is a radiographic marker of early tissue injury in cerebral venous thrombosis (CVT) associated with poor outcomes, yet its mechanistic pathway remains unclear. We investigated whether intraparenchymal hemorrhage (IPH) mediates the association between CE and outcomes. We conducted a retrospective cohort study using the multicenter CLOT-VENUS registry, including acute CVT patients treated at two Comprehensiv...

In many parts of the world, natural resources are primarily managed by governance arrangements at the local level. Those arrangements range from collective, such as cooperatives and associations, to individualistic, such as patrons and owner‐operators. A key question is how such arrangements influence resource use and associated social and ecological outcomes. We hypothesize that sustainable resource use is not associated with...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...