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Improving cognitively healthy survival is important for achieving healthy aging. Therefore, it would be valuable to estimate the future risk of either incident dementia or death in community-dwelling older adults. This study aimed to develop a set of risk prediction models for either incident dementia or death that can be applied according to data availability across diverse clinical settings, using longitudinal data from comm...
Isomaltooligosaccharides Production Using α-Glucosidase Activity from Zalaria sp. Him3, a Fructooligosaccharides-Producing YeastNARA Subscribed
In this study, we aimed to develop isomaltooligosaccharides (IMO) production as a novel industrial application of Zalaria sp. Him3, fructooligosaccharides (FOS)-producing yeast. A utilization test of carbon sources by Zalaria sp. Him3 was performed using API 50CH. Subsequently, the strain was cultivated in maltose medium, and the culture supernatant was used as α-glucosidase (AGase). AGase activity was evaluated by determining...
Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. This cross-sectional study investigated the associations between dietary patterns, dementia, and WMLs in a large, nationwide, multicenter population of older Japanese adults. A total of 8,938 adults (aged ≥ 65; 73 ± 6.3 years old) from the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD...
Genetic basis for the evolution of pelvic‐fin brooding, a new mode of reproduction, in a Sulawesian fishNARA Subscribed
Modes of reproduction in animals are diverse, with different modes having evolved independently in multiple lineages across a variety of taxa. However, an understanding of the genomic change driving the transition between different modes of reproduction is limited. Several ricefishes (Adrianichthyidae) on the island of Sulawesi have a unique mode of reproduction called “pelvic‐fin brooding,” wherein females carry externally fe...
Detailed clinical features and genotype–phenotype correlation in an OTOF-related hearing loss cohort in JapanNARA Subscribed
Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype–phenotype correlation in patients with OTOF mutations is not yet fully under...