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Introduction The investigation was performed to compare the influence of using different pituitary gland extract types (dried and fresh) from common carp ( Cyprinus carpio ) and African catfish ( Clarias gariepinus ) on fecundity, sex hormones, and artificial spawning performance of African catfish. Methods Pituitary glands were collected from sixty-four male catfish and sixty-four carp broodstocks to formulate four treatments...
Pimenta racemosa extract ameliorates chemically induced ulcerative colitis in rats by suppressing inflammation and oxidative stressNARA Subscribed
Pimenta racemosa ( P. racemosa ) tree leaves are used in traditional medicine to alleviate flatulence and gastrointestinal disorders. Ulcerative colitis (UC) is a gastrointestinal inflammatory disease with well-known inflammatory and immunoregulatory pathological features. The complexity of the disease requires multi-targeted treatment. Because of their relative safety and effectiveness, natural products can be utilized as adj...
Date Palm Seed Extract (DPSE) is known to possess beneficial health-promoting and growth-boosting properties, but its specific influence on whiteleg shrimp ( Litopenaeus vannamei) health and physiology has yet to be fully explored. Hence, this study examined how dietary DPSE inclusion impacted growth performance, antioxidant status, immune response, hepatic tissue health, inflammation-related gene expression, and resistance to...
The most common and widely used technique for water and wastewater treatment is membrane separation. This research was applied to fabricate an eco-friendly, low-cost, and sustainable geopolymer membrane that can be used in water treatment. A geopolymer membrane is fabricated using fired clay brick waste, the effect of several variables on the apparent porosity, compressive strength of the membrane, iron and manganese rejection...
The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental health disorders. Among the available interventions, gut microbiota modulators (GMMs) such as probiotics and prebiotics have demonstrated significant potential in infection prevention and neuroprotection. Despite these encouraging findings, the cli...
This study evaluated the viability of using groundwater (GW) compared to seawater (SW) in European sea bass ( Dicentrarchus labrax ) aquaculture. Wild broodstock were captured 2 months before spawning and acclimated to tanks with either SW or GW 1 week prior. Females received HCG injections in both water types. Fertilized eggs were collected into six conical tanks supplied with SW or GW. At 7 days post-hatch (dph), larvae were...
Protective potential of bempedoic acid as an AMPK activator in tamoxifen-induced steatohepatitis in ratsNARA Subscribed
Despite the beneficial therapeutic effects of tamoxifen (TAMX) against breast cancer, long-term treatment with TAMX enhances the development of metabolic dysfunction-associated steatotic liver disease (MASLD), including steatohepatitis. Bempedoic acid (BA) is a recently approved lipid-lowering drug for dyslipidemia. Our study aimed to examine the potential impact of BA against TAMX-induced steatohepatitis in rats and underline...
Whole genome sequencing identifies monogenic disease in 56.1% of families with early-onset steroid-resistant nephrotic syndromeNARA Subscribed
Genetic causes of steroid-resistant-nephrotic-syndrome (SRNS) represent a rapidly growing number of monogenic diseases. The reported diagnostic yield of various studies applying genetic panels and exome-sequencing to diagnose SRNS is usually < 30%. We performed genome-sequencing in a cohort of Egyptian SRNS patients. We recruited 47 SRNS patients belonging to 41 unrelated families [28 males/19 females; median (range): 6 (0.5–2...