Improving cognitively healthy survival is important for achieving healthy aging. Therefore, it would be valuable to estimate the future risk of either incident dementia or death in community-dwelling older adults. This study aimed to develop a set of risk prediction models for either incident dementia or death that can be applied according to data availability across diverse clinical settings, using longitudinal data from comm...

Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. This cross-sectional study investigated the associations between dietary patterns, dementia, and WMLs in a large, nationwide, multicenter population of older Japanese adults. A total of 8,938 adults (aged ≥ 65; 73 ± 6.3 years old) from the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD...

A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the...

Purpose This study aimed to examine changes in salivary immunoglobulin A (s-IgA) secretion at different intensities or durations of acute exercise. Methods Twelve healthy untrained young males were included in randomized crossover trials in Experiment 1 (cycling exercise for 30 min at a work rate equivalent to 35%, 55%, and 75% maximal oxygen uptake [ $${\dot{\text{V}}}$$ V ˙ O 2max ]) and Experiment 2 (cycling exercise at 55%...