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Molecular characterization of a new emaravirus infecting Clerodendrum thomsoniae plantsNARA Subscribed
High-throughput sequencing revealed a new emaravirus named clerodendrum yellow blotch virus (ClYBV), infecting Clerodendrum thomsoniae plants in São Paulo State, Brazil. Four genomic RNA segments (RNA1, RNA3, RNA4, and RNA5) were recovered, whereas RNA2 remained undetected. Phylogenetic analysis and pairwise comparisons based on amino acid sequences showed ClYBV is most closely related to redbud yellow ringspot-associated viru...
On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D PrintingNARA Subscribed
Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...
Mitragynine reduces methamphetamine self-administration in rats without disrupting food-maintained respondingNARA Subscribed
Rationale Kratom ( Mitragyna speciosa ), a plant native to Southeast Asia, has become popular in the United States for its reported ability to treat substance use disorders (SUD). Mitragynine (MG) is the most abundant alkaloid found in kratom. Objectives The present studies evaluated whether MG decreases methamphetamine self-administration under both fixed-ratio (FR) and progressive-ratio (PR) schedules. In a separate cohort w...
Estimating chlorophyll-a (Chl-a) concentrations from satellite ocean color data remains challenging in the Arctic, where freshwater inputs, colored dissolved organic matter (CDOM), suspended particles, and low sun elevation alter optical properties and influence blue–green reflectance. Here, we combine satellite and in situ observations to examine how freshwater-driven optical variability shapes satellite-derived Chl-a across...
Topographic Barriers and Lowland Corridors Structure Gene Flow in the Chagas Vector Rhodnius pallescens Across the Isthmian ForestsNARA Subscribed
Aim Biogeographic processes can profoundly shape the connectivity and evolutionary potential of arthropod disease vectors. We investigated how Panama's ecological and topographic transitions structure populations of the kissing bug Rhodnius pallescens , the primary vector of the Chagas disease agent Trypanosoma cruzi in the region. Location Central America. Period Present. Methods Using 3RAD sequencing, we analysed genome‐wide...
Individual Trees Respond to 40 Years of Climate Change Through Leaf Functional Trait AcclimationNARA Subscribed
Forests are vital for regulating climate and sustaining biodiversity, but climate change threatens their ability to do so, especially in the tropics. Our knowledge of how tropical forests and their constituent trees will respond to changes in climate is largely based on functional trait studies; however, few previous studies have investigated trait changes within individual tropical trees across decades, limiting our ability t...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Animals maintain close associations with diverse microbiota that inhabit their digestive tracts, and these associations can profoundly affect host physiology and fitness. Gut microbiome composition is shaped by both host traits and environmental factors, yet the relative importance of these forces remains unclear in many taxa, including squamate reptiles (lizards and snakes). To address this gap, we analysed the gut microbiome...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Extreme sea levels along the Mexican coasts pose an increasing risk to coastal infrastructure and communities, particularly under the combined influence of tropical cyclones and ongoing sea-level rise. This study analyzes tide-gauge records from the Mexican Pacific and Gulf of Mexico–Caribbean coasts to characterize the statistical behavior and seasonal modulation of extreme sea-level residuals. Astronomical tides were removed...