L. Machado results 328
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Understanding how genetic variants influence disease risk through molecular mechanisms remains a central challenge in complex disease genetics. Nonsyndromic orofacial clefts (OFCs) exemplify this challenge, with most risk loci residing in non-coding regions. We hypothesized that common genetic variants influence OFC risk by modulating DNA methylation at regulatory elements through methylation quantitative trait loci (meQTLs)....
The pygmy ( Kogia breviceps ) and dwarf ( Kogia sima ) sperm whales are cryptic cetaceans characterized by inconspicuous surfacing behavior, small group sizes, and deep‐diving habits, making visual detection particularly challenging. Here, we present the first broad‐scale passive acoustic monitoring (PAM) assessment of Kogia spp. occurrence along the Brazilian coast, spanning both the Equatorial Atlantic Ocean (EAO) and Southw...
Altered hippocampal lipid profile underlies anxiety-like behavior secondary to mild traumatic brain injuryNARA Subscribed
Traumatic brain injury (TBI) remains a major cause of neurological morbidity worldwide, and mild TBI (mTBI) is frequently associated with emotional disturbances, including anxiety-like behavior. Although classical mechanisms of secondary injury have been extensively characterized, metabolic alterations, particularly those involving cerebral lipid homeostasis, remain incompletely defined. Given the structural and regulatory rol...
Aim We evaluated how native vegetation cover influences the diversity of arachnid assemblages across multiple spatial scales in major Brazilian ecosystems. Location Brazil (Amazon and Atlantic rainforests, Cerrado savanna and Caatinga dry forest). Taxon Arachnida (Opiliones, Pseudoscorpiones and Scorpiones). Methods We sampled arachnids at 120 sites using active search and litter sifting. Native vegetation cover was quantified...
Pyrrhulina australis Eigenmann & Kennedy, 1903, is widely distributed across the main hydrographic basins of South America. The taxonomic integrity of this species is nevertheless challenged by the lack of clear diagnostic characters, its marked geographic variation and the morphological overlap with its congeners. In this context, the present study investigated the genetic diversity of the P. australis group ( P. australis ,...
Membrane distillation (MD) is a promising technology for the sustainable treatment of textile industry wastewater. This study investigates the development and performance of polyvinylidene fluoride (PVDF) mixed-matrix membranes (MMMs) incorporating varying concentrations of graphene (0.25–3.00 wt%) for direct contact membrane distillation (DCMD). The membranes were characterized by SEM, AFM contact angle, porosity, and Zeta po...
Random mutagenesis combined with genome-scale analysis represents a powerful approach to uncover metabolic reprogramming in non-model microalgae. In this study we investigated the strain Desmodesmus sp. Petrobras/FURG, a thermotolerant and contamination-resistant microalga with potential for large-scale cultivation. UV mutagenesis followed by iodine-vapor screening yielded the starch-deficient mutant tN-30, which maintained wi...