L. Saunders results 117
· Newest (Page 1/5, per page 25)
Author: L. Saunders ×Clear All Filters
Search Results
Conservation practitioners face the complex challenge of addressing global biodiversity threats within social-ecological systems with multiple jurisdictions, numerous interest groups, and changing environmental conditions. Bridging the research-to-implementation gap between scientists and managers, which integrates diverse perspectives that represent the variety of considerations impacting management outcomes can help to infor...
Understanding cachexia and muscle dysfunction in the context of metastatic breast cancerNARA Subscribed
Cancer cachexia significantly impacts the quality of life of cancer patients, predicting therapy response and survival. Cachexia prevalence and severity increases over the course of disease progression, affecting up to 80% of patients with metastatic cancer. Despite this, cachexia is relatively understudied in the context of metastatic breast cancer, despite it affecting a significant proportion of patients with this common ca...
Cardiac structure and systolic function in resistance-trained athletes versus untrained male adultsNARA Subscribed
Purpose Research examining the Athlete’s Heart has often focused on endurance athletes, yet no clear consensus has emerged on the cardiac adaptations observed in resistance-trained athletes. The purpose of this study is to examine cardiac structure and systolic function in resistance-trained athletes compared to untrained individuals. Methods An observational cross-sectional study conducted echocardiographic examinations on ma...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Purpose In Australia, cervical screening is usually offered face-to-face through primary care. As self-collection offers flexibility in how and where screening can be accessed, we assessed participant preferences for flexible screening models. Methods We recruited women and people with a cervix aged 24–74 years into a national survey (December 2023–April 2024) via a paid Meta campaign and community networks. Sociodemographic f...
Signals From the Southern Edge: Demographic Effects of Ocean Warming on Two Cold‐Adapted Seabird Species in the Gulf of MaineNARA Subscribed
Rapid warming in the Gulf of Maine (GoM) is contributing to widespread shifts in the abundance, distribution, and quality of marine prey communities. These shifts cascade up the food web and will ultimately affect the fitness and viability of seabirds, the impacts of which are expected to be especially pronounced at the southern edge of their ranges. Using integrated population models, we analyzed 26 years (1998–2023) of demog...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Seasonal Exposure to Hemispheric Conservation Challenges Influences Population Trends of Migratory Warblers (Parulidae)NARA Subscribed
Human activities have profound impacts on ecological systems and biodiversity worldwide. Estimating wildlife response to those activities across broad spatial scales is challenging, yet effective conservation measures require an understanding of where and when these activities are contributing to population declines. We investigated the relationship between exposure to human activities (conservation challenges) and population...
Good data relations key to Indigenous research sovereignty: A case study from NunatsiavutNARA Subscribed
Although researchers are committed to Indigenous data sovereignty in principle, they fall short in returning data and results to communities in which or with whom they conduct their research. This results in a misalignment in benefits of research toward researchers and settler institutions and away from Indigenous communities. To explore this, we conducted a case study analyzing the rate researchers returned data to Nunatsiavu...
Background and aims An overlooked fraction of the terrestrial carbon (C) pool is that associated with biogenic silica deposited in plants (phytoliths), so-called PhytOC. This fraction is small compared with the main C pools, but is of interest because it could be a long-term C sink as phytoliths may protect organic C from mineralization. However, the topic is hotly contested and unclear due to both methodological and theoretic...
Striated muscle: an inadequate soil for cancersNARA Subscribed
Many organs of the body are susceptible to cancer development. However, striated muscles—which include skeletal and cardiac muscles—are rarely the sites of primary cancers. Most deaths from cancer arise due to complications associated with the development of secondary metastatic tumours, for which there are few effective therapies. However, as with primary cancers, the establishment of metastatic tumours in striated muscle acc...