Purpose The study examined the acute muscle and systemic physiological responses to a 5v5 small-sided game (SSG) of football in trained female players. Methods Ten trained female football players (age: 24.5 ± 1.9 years, height: 169 ± 5 cm, weight: 67.0 ± 8.0 kg, fat%: 24.8 ± 7.6%) completed four 12-min periods of play (P1-P4) with 4-min passive recovery. Muscle biopsies were obtained from m. vastus lateralis pre- and post-game...