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Background Estrogens exert a beneficial effect on metabolism. Women carrying BRCA likely pathogenic/pathogenic variants (LP/PV) are at increased risk of premature menopause and may therefore be at higher risk of developing metabolic disorders later in life. In this single-center prospective cohort study, we investigated whether the specific BRCA mutation ( BRCA 1 vs. BRCA 2) has a differential impact on metabolism in women. Me...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
ENDURUNS: An Integrated and Flexible Approach for Seabed Survey Through Autonomous Mobile VehiclesOA Marine
The oceans cover more than two-thirds of the planet, representing the vastest part of natural resources. Nevertheless, only a fraction of the ocean depths has been explored. Within this context, this article presents the H2020 ENDURUNS project that describes a novel scientific and technological approach for prolonged underwater autonomous operations of seabed survey activities, either in the deep ocean or in coastal areas. The...
Forecasting of jack mackerel landings ( T rachurus murphyi ) in central‐southern C hile through neural networksNARA Subscribed
In the present study, the performance of neuronal networks models in monthly landing forecasting of jack mackerel ( T rachurus murphyi ) in central‐southern C hile (32°S–42°S) was assessed. Thus, monthly estimations for 10 environmental variables, fishing effort (fe) and jack mackerel landings for the period 1973–2008 were used. A preliminary analysis was done in order to remove strongly correlated variables. Sea surface tempe...
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