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Anticipating future socioeconomic conditions through scenarios supports effective land-use planning and management that safeguards biodiversity and ecosystem services (BES). This study introduces a novel participatory scenario development protocol to design consistent, nested regional scenarios tailored for BES assessments of agricultural land-use. The protocol is applied in four European case studies (subnational regions in A...
Acute exposure to high concentrations of polystyrene nanoparticles induces genotoxicity in Daphnia pulexNARA Subscribed
Micro- and nanoplastics (MNPs) are known to detrimentally impact a wide range of aquatic species, inducing mortality, decreased growth, a reduction in offspring production and increase in reactive oxygen species in their tissues. However, the genotoxic impact of MNPs in freshwater organisms remains understudied. In the present study we investigate the genotoxic impact of acute exposure to polystyrene nanoparticles (PSNPs) in D...
Due to their importance in global ocean ecology and biogeochemistry, much is known about the abundance and diversity of marine microbes and this data informs our studies of microbial genetic variability and niche partitioning. However, much less is known about marine microbes’ vital rates, including phylogenetically-resolved intrinsic growth and mortality. Here, we use cyanobacteria to validate a recently-developed, sequence-b...
Living in the middle of the edge: an insight into ancient subsistence practices in MyanmarNARA Subscribed
The origins of agriculture have been a focal point of interest in Southeast Asia because of the profound influence domestication of cereal crops had on the ancient inhabitants of the region. Historically, an emphasis has been placed on the movement of farmers from China into Southeast Asia during the Neolithic, however, the origin of agriculture in Myanmar remains unknown. Recently, stable carbon and oxygen isotope analyses ha...
Exploring agroforestry limiting factors and digitalization perspectives: insights from a european multi-actor appraisalNARA Subscribed
Despite its potential for fostering farm sustainability, the adoption of agroforestry faces context-dependent challenges, among which the (perceived) shortage of decision-supporting tools and barriers hindering the assessment of economic, environmental, and social benefits. The process of digitalization offers significant opportunities to enhance sustainability, but it remains crucial to foster a human-centric, fair, and susta...
Dense, cold waters formed on Antarctic continental shelves descend along the Antarctic continental margin, where they mix with other Southern Ocean waters to form Antarctic Bottom Water (AABW). AABW then spreads into the deepest parts of all major ocean basins, isolating heat and carbon from the atmosphere for centuries. Despite AABW’s key role in regulating Earth’s climate on long time scales and in recording Southern Ocean c...
Summer Clinical Oncology Research Experience (SCORE) Program: Engaging Undergraduates from Diverse Backgrounds in Cancer ResearchNARA Subscribed
Diversifying the future cancer research workforce requires that students engage in cancer research, persist in paths toward science, technology, engineering, mathematics, and medicine (STEMM) fields, and choose cancer research careers. The Summer Clinical Oncology Research Experience (SCORE) Program at Memorial Sloan Kettering, designed in 2010 to engage undergraduate (U) and post-baccalaureate (PB) students from diverse backg...
Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New OpportunitiesNARA Subscribed
Population studies show worrisome trends towards earlier breast development, difficulty in breastfeeding, and increasing rates of breast cancer in young women. Multiple epidemiological studies have linked these outcomes with chemical exposures, and experimental studies have shown that many of these chemicals generate similar effects in rodents, often by disrupting hormonal regulation. These endocrine-disrupting chemicals (EDCs...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
High concentrations of pharmaceuticals emerging as a threat to Himalayan water sustainabilityNARA Subscribed
The sixth UN Sustainable Development Goal, Clean Water and Sanitation, directly underpins other goals of Health, Life in Water and Sustainable Cities. We highlight that poor sanitation, exemplified through some of the highest concentrations of pharmaceuticals ever detected in rivers, will amplify societal and environmental stress where climate-induced reductions in flow are predicted. Rapidly growing urban centres with inadequ...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Within the Ararat Valley (Armenia), a continuously growing water demand (for irrigation and fish farming) and a simultaneous decline in groundwater recharge (due to climate change) result in increasing stress on the local groundwater resources. This detrimental development is reflected by groundwater-level drops and an associated reduction of the area with artesian conditions in the valley centre. This situation calls for incr...