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Obesity, characterized by excessive accumulation of body fat, is associated with reduced vitamin D levels. Several polymorphisms of the vitamin D receptor exist, such as TaqI (rs731236), although their association with obesity remains inconsistent. The aim of this study was to evaluate the effect of TaqI polymorphism on biomarkers in individuals with obesity. The study has been approved by the Research Ethics Committee of the...
During postnatal development in mice there is a marked switch in the expression of AQP4 from white to grey matter regions. A microglial population, CD11c+, which has been shown to be involved in normal postnatal development of the corpus callosum (CC), prolongs its expression in this tissue in the absence of AQP4. Here, we investigated the correlation between the levels of AQP4 expression during the early postnatal period and...
Monoclonal antibodies (mAbs) are promising therapeutic agents for neurological disorders due to their high specificity. However, their clinical application is significantly hindered by their poor transport across the blood-brain barrier (BBB) and their limited diffusion within the brain parenchyma. While significant efforts have been oriented to tackle the first barrier, the challenge of efficient brain diffusion remains large...
Disinfection methods to obtain axenic cultures of Posidonia oceanica seedlings germinated from beach cast fruitsNARA Subscribed
The regeneration of seagrass meadows through restoration efforts relies heavily on transplantable plant material, which is currently sourced from natural populations. However, the availability of this material is limited due to the lack of established axenic micropropagation protocols, highlighting the need for further research in this area. A major challenge in Posidonia oceanica micropropagation is explant disinfection, whic...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...