During postnatal development in mice there is a marked switch in the expression of AQP4 from white to grey matter regions. A microglial population, CD11c+, which has been shown to be involved in normal postnatal development of the corpus callosum (CC), prolongs its expression in this tissue in the absence of AQP4. Here, we investigated the correlation between the levels of AQP4 expression during the early postnatal period and...

Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascularization strategy whereby tumor cells utilize pre-existing host vessels. Co-opted vessels have been considered refractory to anti-angiogenic therapies, and pharmacological modulation of co-...

Attentionally directed oculomotor training may engage circuits implicated in gamma-band modulation and early Alzheimer’s disease (AD) pathophysiology, yet its effects across mild cognitive impairment (MCI) risk strata remain unclear. We aimed to determine whether this training, delivered through a gamified eye-tracking task, is associated with differential effects on plasma neurodegeneration biomarkers, cognitive performance,...

Coal is a major global energy resource, but its extraction raises significant environmental and health concerns. Mining activities release large amounts of particulate matter, including nanoparticles (NPs), into the environment. These NPs are hazardous due to their content of polycyclic aromatic hydrocarbons (PAHs), metals, oxides, and other compounds capable of disrupting cellular and molecular processes. This study evaluated...

Morphological evidence suggests that European Middle Pleistocene hominins share a common phylogenetic history, yet they display a substantial morphometric variability. In particular, MIS 7 − 5 hominins have been proposed to exhibit a distinctive combination of traits differentiating them from both earlier and later Neanderthal populations. However, the scarcity of fossil remains from this period limits our understanding of Nea...

Human‐induced high densities of large wild herbivores may pose a threat to natural ecosystems, modifying biodiversity and ecosystem functioning. Although the negative impacts on individual taxa and processes are well documented, a comprehensive understanding of how ecosystem integrity responds to high herbivore densities remains limited. This study addresses this gap through an extensive herbivore‐density manipulation experime...

Coral reef systems on the southeastern Cuban shelf are exposed to rapid warming and increasingly frequent marine heatwaves (MHWs). However, the physical drivers of local sea-surface temperature (SST) variability remain poorly quantified. The present study examines seasonal-to-decadal SST variability in and around the Jardines de la Reina National Park (JRNP) and investigates the extent to which atmospheric–ocean processes and...