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MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBCNARA Subscribed
Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activation of the MAPK signaling pathway decreases the levels of tumor-infiltrating lymphocytes in triple-negative breast cancer (TNBC) and is associated with worse survival. Here, we investigated...
Octocorals are an important component contributing to habitat forming that enhances the three-dimensional structural complexity and facilitates benthic–pelagic coupling for marine benthic ecosystems. Studies on octocorals in marginal environments could provide insight to researchers and conservationists in the face of the deteriorating seascape under the Anthropocene. The octocoral communities in Hong Kong persist under margin...