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Commercial and on-farm microbial bioinputs production systems: challenges, opportunities and current Brazilian regulatory frameworkNARA Subscribed
Microbial bioinputs have emerged as an innovative solution to more sustainable agriculture, with microorganisms playing diverse roles in plants. The increasing adoption of bioinput requires efficient production systems, which can be industrial facilities or on-farm biofactories - self-use units installed on rural properties. Thus, evaluating the opportunities and potential risks associated with bioinput production, particularl...
Bacterial diseases associated with the Mollicutes class can lead to decreased milk production and reproductive disorders in cattle, causing significant economic losses and compromising animal welfare. This study aimed to investigate the presence of Mollicutes and Ureaplasma diversum in the reproductive tract of dairy cows and determine the associated risk factors, as well as identify circulating strains of Ureaplasma in herds....
Brief report: attitudes and barriers toward genetic testing in pleural mesothelioma: a nationwide Italian surveyNARA Subscribed
Pleural mesothelioma (PM) is a malignancy with a relevant genetic component, with germline mutations identified in up to 12% of cases. International guidelines recommend universal germline testing; however, its implementation in routine clinical practice remains inconsistent. This nationwide survey aimed to assess current clinical practice, attitudes, and barriers related to genetic testing among Italian specialists within the...
Bundesweite Entwicklung der Grundwasserstände seit 1991: Langzeittrends, Variabilität und Auswirkungen der jüngsten TrockenphaseNARA Subscribed
Zusammenfassung Die Studie untersucht die Entwicklung der Grundwasserstände in Deutschland anhand von 5844 Messstellen sowie deren Reaktionsdynamik gegenüber klimatologischen Antrieben im Referenzzeitraum 1991–2020. Zusätzlich wird die Entwicklung seit 2018 im Kontext der außergewöhnlichen Dürreperiode betrachtet, um die Reaktionsfähigkeit und Vulnerabilität der Grundwassersysteme gegenüber extremen klimatischen Bedingungen zu...
Among the few species of Microcambeva reported as occurring in more than one hydrographic basin, M. ribeirae has been previously listed from both the Ribeira de Iguape and the Guaraqueçaba basins. However, morphological and molecular analyses revealed that the specimens from Guaraqueçaba represent a new species, which is described in this study. Therefore, the distribution of M . ribeirae is restricted to the Ribeira de Iguape...
Tectonic activity plays a significant role in fossil recovery within the Brejo das Freiras Sub-basin, Rio do Peixe Basin, influencing both fossil abundance and preservation state. In this study, lithological data from 203 cutting samples were used; 73 samples were analysed for calcareous microfossils. Additionally, 20 samples were selected for sedimentary organic matter analyses to support and refine the palaeoenvironmental in...
This study presents the results of monitoring the endangered gastropod Patella ferruginea within a Marine Protected Area in Sardinia. A detailed map of the species distribution was created, and individual density and population structure were analysed by comparing data collected during monitoring campaigns in 2014, 2018, and 2023. A total of 206, 203, and 109 individuals were recorded in 2014, 2018, and 2023, respectively. In...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Location of oncogene-induced DNA damage sites revealed by quantitative analysis of a DNA counterstainNARA Subscribed
Oncogene activation is a key driver of cancer development, inducing aberrant cellular proliferation and DNA replication stress. This in turn, leads to DNA damage—which accumulates in specific genomic regions—contributing to genomic instability in cancer. However, the interplay between oncogene-induced DNA damage and chromatin organization is still poorly understood. In this study, we introduce a QUantitative ANalysis of DNA cO...