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From insult to hyperexcitability: pharmacological targeting of MyD88 and JAK/STAT3 pathways in epilepsyNARA Subscribed
Neuroinflammation is hypothesized to be a fundamental driver of epileptogenesis, potentially contributing to the transformation of the healthy brain into a state prone to spontaneous recurrent seizures. This manuscript explores the pivotal roles of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) in modulating neuronal excitability and structural plasticity. We delineate how the activation of the...