Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....

Peutz-Jeghers Syndrome (PJS) is caused by germline pathogenic variants in the STK11 gene and is associated with elevated lifetime risks for several cancers, including lung cancer. Currently, no formal recommendations exist for lung cancer screening in PJS. This structured narrative review compares lung cancer risk in PJS with lung cancer risk in individuals currently eligible for screening based on age and smoking history. Pub...

Serum glial fibrillary acidic protein (sGFAP) is an astroglial biomarker preliminarily investigated in acute ischemic stroke (AIS). We aimed to investigate its temporal pattern and clinical value in two German AIS cohorts. Using immunoassay, we measured sGFAP concentrations in 952 samples of 572 AIS patient and 32 samples of controls recruited in Halle [AIS n = 102, age: 70.9 (± 15.9) years, 52.0% males; controls n = 32, age:...

Di-n-butyl phthalate (DBP) is a conventional plasticizer known to induce hepatotoxicity and nephrotoxicity through oxidative stress and apoptosis. In contrast, curcumin, a polyphenolic compound from Curcuma longa , has significant antioxidant and anti-apoptotic activity; however, its therapeutic efficiency is limited due to poor absorption and low bioavailability. Nanoliposomes can significantly enhance the stability and absor...

Animals maintain close associations with diverse microbiota that inhabit their digestive tracts, and these associations can profoundly affect host physiology and fitness. Gut microbiome composition is shaped by both host traits and environmental factors, yet the relative importance of these forces remains unclear in many taxa, including squamate reptiles (lizards and snakes). To address this gap, we analysed the gut microbiome...