The sheep lung has long been used to model aspects of the human lung, both its normal development and pathological changes that occur in ovine models of lung disease. The similarities between the two species provide an opportunity to investigate phases of lung development that are not accessible for investigation in humans, for example later in gestation. Here we use single cell (sc) RNA-seq to investigate the developmental dy...

Eurasian otters Lutra lutra are protected in Europe and vulnerable due to low reproductive rates. The ability to age cubs may be important to identify and protect breeding places and target seasonal surveys, yet little data exists. We developed a novel method to measure cubs relative to their mother using on-screen pixels on camera trap footage. We tested this on domestic ferrets Mustela furo of known length, then applied it t...

Constructed value of information (CVoI) is an expert elicitation decision‐analytic tool used to prioritize sources of uncertainty based on their potential to improve decision outcomes if resolved. Despite increased application of CVoI, the robustness of CVoI prioritization of sources of uncertainty relative to differences in expert elicitation and scoring methods has not been evaluated. We engaged a group of species experts in...

Staphylococcus aureus bloodstream infections are a significant risk for hemodialysis patients, who would significantly benefit from a preventative vaccine. To-date S. aureus vaccine trials have failed, in part due to lack of consideration of pre-existing immune imprints in relevant patient cohorts. Using a machine learning algorithm this study revealed, prior S. aureus exposure in a cohort of 180 hemodialysis patients, was ass...

Acute ischemic stroke (AIS) remains a leading cause of disability worldwide, and effective treatments are urgently needed beyond reperfusion therapy. Translating preclinical success to clinical impact has been hindered by variability in animal models and the lack of translational biomarkers that predict outcomes across species. To overcome these barriers, we developed a robust rat AIS model optimized for consistency and severi...

Differential tree species response to a changing climate could serve to drive changes in tree species dominance that alter forest ecosystem dynamics and have cascading socio-ecological impacts. This study projected climate change–driven shifts in tree species dominance across Canada’s forests by the end of the twenty-first century. To do this, we mapped predictions of dominant tree species under possible future climate conditi...