M. Weiss results 296
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Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve ClosureNARA Subscribed
Purpose Many approaches have been used to model chordae tendineae geometries in finite element simulations of atrioventricular heart valves. Unfortunately, current “functional" chordae tendineae geometries lack anatomical fidelity (e.g., branching) that would be helpful when informing clinical decisions. The objectives of this work are (i) to improve synthetic chordae tendineae geometric fidelity to consider branching and (ii)...
A Geometric Feature Tracking Approach for Noninvasive Patient-Specific Estimation of Leaflet Strain from 3D Images of Heart ValvesNARA Subscribed
Purpose: Valvular heart disease is prevalent and a major contributor to heart failure. Valve leaflet strain is a promising metric for evaluating the mechanics underlying the initiation and progression of valvular pathology. However, generalizable methods for noninvasively quantifying valvular strain from clinically acquired patient images remain limited. This study aims to develop a robust feature tracking framework that enabl...
Polar Winter Processes: An Under-Represented Research Focus within the Coupled Earth SystemNARA Subscribed
Observing winter processes during the extended cold season is crucial not only for understanding polar and global coupled Earth system but also for enhancing capability of year-round prediction, especially in the context of Arctic amplification and the drastic decrease in sea ice extent and thickness at both poles. However, harsh environmental conditions and logistical challenges have left polar winter Earth system processes s...
Peutz-Jeghers Syndrome and lung cancer: does the risk meet the threshold for lung cancer screening?NARA Subscribed
Peutz-Jeghers Syndrome (PJS) is caused by germline pathogenic variants in the STK11 gene and is associated with elevated lifetime risks for several cancers, including lung cancer. Currently, no formal recommendations exist for lung cancer screening in PJS. This structured narrative review compares lung cancer risk in PJS with lung cancer risk in individuals currently eligible for screening based on age and smoking history. Pub...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
In the modern healthcare landscape, many patients turn to online platforms for information about their diagnoses and treatment options. This study assessed 14 acute myeloid leukemia (AML) websites for their understandability and actionability using the Patient Education Materials Assessment Tool (PEMAT). Fourteen patient-facing US AML websites were searched in Google, selected, and analyzed using the PEMAT criteria. PEMAT is a...
Integrated Reanalysis of Global Riverine Fish eDNA Datasets Shows Robustness and Congruence of Biodiversity ConclusionsNARA Subscribed
The analysis of environmental DNA (eDNA) has revolutionized biodiversity assessments in aquatic ecosystems, enabling non‐invasive monitoring of fish communities across diverse regions. However, the global comparability of these eDNA datasets remains ambiguous due to heterogeneous sampling protocols and bioinformatic workflows across studies, making it difficult to assess how robust and comparable the biodiversity patterns infe...
Laboratory Transmission of Adult Salmon Enteritis and Associated Pathogens in Juvenile Chinook Salmon ( Oncorhynchus tshawytscha )NARA Subscribed
Adult salmon enteritis (ASE), characterised by severe ulcerative enteritis, has been linked to prespawn mortality (PSM) in spring Chinook salmon ( Oncorhynchus tshawytscha ) in certain rivers in Oregon, USA. Catastrophic losses of spring Chinook salmon have resulted from PSM, a significant threat to their population stability. Understanding the causes of ASE is therefore critical for mitigating PSM and supporting conservation....
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
A tale of two agricultural revolutions: crop introductions in the long 1st millennium ce southern LevantNARA Subscribed
This paper aims to provide a robust regional synthesis of crop diffusion in the southern Levant, with the objective of ascertaining the significance of 1st millennium ce introductions, including those associated with Roman Agricultural Diffusion (RAD) and the Islamic Green Revolution (IGR). It does so by integrating published archaeobotanical data and written evidence from multiple periods to identify the earliest attestations...