M.J. Groot results 106
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Tracking biodiversity in changing Arctic waters: insights from eDNA metabarcoding in SvalbardNARA Subscribed
Monitoring biodiversity patterns and their changes in Arctic coastal ecosystems is critical under ongoing climate change. However, common current approaches require high effort and expertise and this in turn limits the spatial and temporal scale of these monitoring efforts. Here, we investigated both the fish and the marine invertebrate communities across Svalbard using a multi-marker environmental DNA metabarcoding approach....
Sleep During NICU Care Is Associated With Proportional Cerebellar Size at Term-Equivalent Age in Extremely Preterm InfantsNARA Subscribed
Background Infants born extremely preterm (< 28 weeks’ gestation) are born during a phase of rapid cerebellar growth, when disturbances in brain maturation are common and reduced cerebellar size has been linked to unfavorable neurodevelopment. During late gestation, sleep is the dominant brain state and provides structured endogenous activity supporting circuit formation. In the neonatal intensive care unit (NICU), sleep may b...
Purpose Type II endoleaks (T2EL) are a common complication after endovascular aneurysm repair. AneuFix is a newly designed elastic polymer for T2EL. AneuFix contains tantalum for visualization during fluoroscopy, which is crucial for monitoring the polymer in the side branches. The purpose of this study was to find the lowest concentration tantalum that is sufficient for safe injection in the aneurysmal sac. Methods AneuFix po...
Vascular Flow Phantom of A Cohort-Based Averaged Abdominal Aortic Aneurysm: Design, Fabrication and CharacterizationNARA Subscribed
Purpose Vascular flow phantoms are an invaluable tool for in vitro and in silico studies, but their design and fabrication processes are often not reported. In this study , a framework is introduced to design and fabricate 3D printable high-fidelity cohort-based averaged abdominal aortic aneurysm (AAA) phantoms. Methods AAA geometries of 50 patients were segmented from preoperative computed tomography angiography scans. The se...
An increase in biotic interactions towards lower latitudes is one of the most consistent patterns in ecology. Higher temperatures and more stable climatic conditions at low latitudes are thought to enhance biotic interactions, accelerating biological evolution and leading to stronger anti-herbivore defences in plants. However, some studies report contradictory findings, highlighting the need for further investigation into the...
The largest light-harvesting antenna in nature, the chlorosome, is a heterogeneous helical BChl self-assembly that has evolved in green bacteria to harvest light for performing photosynthesis in low-light environments. Guided by NMR chemical shifts and distance constraints for Chlorobaculum tepidum wild-type chlorosomes, the two contrasting packing modes for syn-anti parallel stacks of BChl c to form polar 2D arrays, with dipo...
Decomposing drivers in avian insectivory: Large‐scale effects of climate, habitat and bird diversityNARA Subscribed
Aim Climate is a major driver of large‐scale variability in biodiversity, as a likely result of more intense biotic interactions under warmer conditions. This idea fuelled decades of research on plant‐herbivore interactions, but much less is known about higher‐level trophic interactions. We addressed this research gap by characterizing both bird diversity and avian predation along a climatic gradient at the European scale. Loc...
Preclinical Models of Cardiac Disease: A Comprehensive Overview for Clinical ScientistsNARA Subscribed
For recent decades, cardiac diseases have been the leading cause of death and morbidity worldwide. Despite significant achievements in their management, profound understanding of disease progression is limited. The lack of biologically relevant and robust preclinical disease models that truly grasp the molecular underpinnings of cardiac disease and its pathophysiology attributes to this stagnation, as well as the insufficiency...
Purpose Rapid diagnosis and treatment of infectious meningitis and encephalitis (ME) is critical to minimize morbidity and mortality. Recently, Qiagen introduced the CE-IVD QIAstat-Dx ME panel (QS-ME) for syndromic diagnostic testing of meningitis and encephalitis. Some data on the performance of the QS-ME in comparison to the BioFire FilmArray ME panel are available. In this study, the performance of the QS-ME is compared to...
Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic TherapeuticsNARA Subscribed
The identification and removal of host cell proteins (HCPs) from biologic products is a critical step in drug development. Despite recent improvements to purification processes, biologics such as monoclonal antibodies, enzyme replacement therapies, and vaccines that are manufactured in a range of cell lines and purified using diverse processes may contain HCP impurities, making it necessary for developers to identify and quant...
Does conduction heterogeneity determine the supervulnerable period after atrial fibrillation?NARA Subscribed
Atrial fibrillation (AF) resumes within 90 s in 27% of patients after sinus rhythm (SR) restoration. The aim of this study is to compare conduction heterogeneity during the supervulnerable period immediately after electrical cardioversion (ECV) with long-term SR in patients with AF. Epicardial mapping of both atria was performed during SR and premature atrial extrasystoles in patients in the ECV ( N = 17, age: 73 ± 7 years) an...
A roadmap for ladybird conservation and recoveryNARA Subscribed
Ladybirds (Coleoptera: Coccinellidae) provide services that are critical to food production, and they fulfill an ecological role as a food source for predators. The richness, abundance, and distribution of ladybirds, however, are compromised by many anthropogenic threats. Meanwhile, a lack of knowledge of the conservation status of most species and the factors driving their population dynamics hinders the development and imple...
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and...
Appreciating and dealing with the plurality of farmers’ perceptions and their contextual knowledge and perspectives of the functioning and performance of their agroecosystems—in other words, their ‘mental models’—is central for appropriate and sustainable agricultural development. In this respect, the sustainable development goals (SDGs) aim to eradicate poverty and food insecurity by 2030 by envisioning social inclusivity tha...
Early detection of marine non-indigenous species on Svalbard by DNA metabarcoding of sedimentNARA Subscribed
Non-indigenous species (NIS) in the Arctic have an increased likelihood of arrival from ship traffic in the region, while the survival potential of the species becomes more likely in a warming environment. Monitoring is essential to detect the rate and magnitude of the establishment of NIS. In this study, a list of 123 potential marine NIS for Svalbard was drafted and the presence of marine NIS in soft sediment of Kongsfjorden...