Rays of the family Rhinopteridae Jordan & Evermann, 1896 are highly migratory and widely distributed in warm tropical and temperate waters. Along the Brazilian coast, the presence of two species has been recorded: Rhinoptera bonasus Mitchill, 1815 and Rhinoptera brasiliensis Müller, 1836. These stingrays are commonly caught as bycatch in trawl fisheries, however, the two species lack distinctive external morphological features...

Chronic kidney disease is an increasing global public health concern, and the Developmental Origins of Health and Disease (DOHaD) concept proposes that adverse conditions during critical developmental windows predispose offspring to chronic disorders later in life. Maternal protein restriction (MPR), a well-established experimental model reflecting food insecurity, has been shown to impair nephrogenesis and promote long-term r...

In this study, we conducted an epidemiological investigation and analyzed the agreement between the Faust technique and the immunochromatographic assay in the diagnosis of Giardia spp. in 272 cats in the municipality of Londrina, Paraná state, Brazil. We identified an overall prevalence of 74.63% (203/272 [95% CI: 69.14–79.44%]) of Giardia spp. in cats, being significantly higher in adult and non-domiciled animals, which prese...

Wild animals often play a role in the transmission of zoonotic pathogens. Among the wild mammals of South America, ring-tailed coatis ( Nasua nasua ) can present a high frequency of anti- Leptospira antibodies and carry Leptospira spp. This study aimed to evaluate the frequency of serum anti- Leptospira antibodies and perform the molecular identification of Leptospira spp. in ring-tailed coatis living in the Tietê River Ecolog...

The anesthetic management of female dogs with mammary neoplasia, usually classified as ASA II and undergoing invasive procedures such as mastectomy and ovariohysterectomy, requires effective sedation and anesthetic stability due to the increased anesthetic risk associated with advanced age and underlying disease. In this context, this study aimed to evaluate the sedative effects and reduction in anesthetic requirements of a fu...

Leptospirosis is a neglected zoonosis with significant impact on public and veterinary health, with equines acting as potential maintenance hosts of infection. This study aimed to investigate the seroprevalence of Leptospira in Lavradeiro horses under semi-feral conditions in Indigenous communities in the state of Roraima, Brazil. A total of 387 serum samples were subjected to the microscopic agglutination test (MAT), using an...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

Expanding integrative cytogenetic and molecular analyses is essential for understanding the evolutionary dynamics of chromosome number variation in fishes. This study presents the first cytogenetic characterization of Hypostomus sertanejo , an endemic species native to the semi-arid Jaguaribe River basin in Northeastern Brazil. Cytogenetic analysis revealed a diploid number of 2n = 52, which is the lowest documented for the ge...

Tumor progression depends on an adequate blood supply to sustain oxygen and nutrients delivery. While tumor angiogenesis involves the formation of new blood vessels from pre-existing ones, vessel co-option represents a non-angiogenic vascularization strategy whereby tumor cells utilize pre-existing host vessels. Co-opted vessels have been considered refractory to anti-angiogenic therapies, and pharmacological modulation of co-...