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Understanding Patterns and Drivers of Changing Sectoral Economic Water Use in ScotlandNARA Subscribed
Understanding economic water use remains challenging due to limited data availability and confidentiality constraints that restrict the robust assessment of sectoral patterns. This study presents the first publicly available national dataset for Scotland that integrates abstraction and network-supplied water volumes across 81 economic sectors, enabling consistent sectoral water-use assessment and ranking of major contributors...
Crop residues are important inputs of carbon (C) and nitrogen (N) to soils and thus directly and indirectly affect nitrous oxide (N 2 O) emissions. As the current inventory methodology considers N inputs by crop residues as the sole determining factor for N 2 O emissions, it fails to consider other underlying factors and processes. There is compelling evidence that emissions vary greatly between residues with different biochem...
Europe has a long history of human pressure on freshwater ecosystems. As pressure continues to grow and new threats emerge, there is an urgent need for conservation of freshwater biodiversity and its ecosystem services. However, whilst some taxonomic groups, mainly vertebrates, have received a disproportionate amount of attention and funds, other groups remain largely off the public and scientific radar. Freshwater mussels (Bi...
Although autografts represent the gold standard for anterior cruciate ligament (ACL) reconstruction, tissue-engineered ACLs provide a prospect to minimize donor site morbidity and limited graft availability. This study characterizes the ligamentogenesis in embroidered poly( L -lactide- co -ε-caprolactone) (P(LA-CL)) / polylactic acid (PLA) constructs using a dynamic nude mice xenograft model. (P(LA-CL))/PLA scaffolds remained...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signalingNARA Subscribed
Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of this pesticide family form a set of diverse metabolites within crops. Among these, desnitro-imidacloprid (DN-IMI) is of special toxicological interest, as there is evidence (i) for human dietary exposure to this metabolite, (ii) and that DN-IMI is a strong...
Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neuronsNARA Subscribed
Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signali...
Major shift in bacterioplankton utilization of enantiomeric amino acids between surfacewaters and the ocean's interiorNARA Subscribed
The peptidoglycan layer of the bacterioplankton cell wall contains four major amino acids (alanine, Ala; serine, Ser; aspartic acid, Asp; and glutamic acid, Glu) in a characteristic enantiomeric ratio (D/L ratio). It is assumed that bacterioplankton are the only biological source of significance for these four specific D‐amino acid species in the ocean. The concentrations of these dissolved total enantiomeric amino acids were...
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