This study evaluates bioremediation using effective microorganisms (EM) to improve quality in the eutrophic Maricá Lagoon (RJ, Brazil). The intervention, implemented in late 2021, consisted of the regular application of EM in one of the lagoon’s main fluvial contributors: the Mumbuca-Ubatiba drainage basin. To evaluate bioremediation, physicochemical and biogeochemical variables were monitored in the water column and sediments...

Bacterial resistance constitutes one of the main threats to global public health, driving the search for therapeutic strategies capable of restoring the effectiveness of antimicrobials. Among the mechanisms involved, efflux pumps stand out, reducing the intracellular concentration of drugs and contributing to multidrug resistance. In this context, inhibitors of these pumps emerge as a promising approach, as they increase the i...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Western dietary patterns are major drivers of cardiometabolic dysfunction, partly mediated by gut microbiome dysbiosis and sustained inflammation along the gut–brain axis. In this study, we investigated whether a synbiotic formulation combining Limosilactobacillus ( L .) fermentum strains with polyphenols, quercetin, and resveratrol could mitigate cardiovascular and neuroinflammatory alterations induced by a Western diet. Male...

The aim of this study was to evaluate the impact of crop diversification on the soil emissions of CO₂, CH₄, and N₂O in soybean production systems under no-till management in the Brazilian Cerrado. Five production systems were analyzed: soybean–maize succession (S1); soybean–Urochloa ruziziensis succession (S2); soybean–crotalaria succession followed by maize intercropped with U. ruziziensis (S3); rotation of soybean and crotal...

Receptor Activity-Modifying Protein 1 (RAMP1) is a Calcitonin Receptor-Like Receptor (CALCRL)-associated protein with significant relevance in oncogenesis and tumor progression. It acts as a context-dependent allosteric modulator of GPCRs. This integrative review synthesizes evidence from multiple omics layers—transcriptomics, proteomics, epigenomics, and pan-cancer datasets—to clarify the role of RAMP1, its signaling pathways...

Localized cutaneous leishmaniasis (LCL) is the most prevalent form of leishmaniasis, with infection control primarily dependent on cell-mediated immunity. Lesion healing results from a complex interplay among immune cells and soluble mediators. Using Luminex technology, we evaluated circulating and lesion microenvironment immune mediators, including chemokines, cytokines, and growth factors, in patients with LCL and nonspecifi...

Fungi of the phylum Ascomycota , recognized for their extraordinary adaptability to extreme environments, play crucial ecological roles, particularly in sea turtle nests, where they are responsible for 61% of fungal occurrences. In this comprehensive review, we aim to synthesize current knowledge on the diversity, ecology, and pathogenicity of fungi associated with sea turtles and their nesting environments, with special atten...