Maria James results 406
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Standardized microhaplotype databases and frameworks for assessing and mining crop genetic diversityNARA Subscribed
Keymessage Standardized microhaplotype databases for eight diverse crops enable multiallelic analyses, comparative genetics, and breeding decisions. Abstract Microhaplotypes are short genomic segments that contain multiple tightly linked variants, providing multi-allelic data that can enhance genetic resolution compared to traditional biallelic single nucleotide polymorphism (SNP) markers. Here, we present the creation and uti...
Embedding Community Engagement in Underrepresented Student Cancer Research Training Programs: A Preliminary ReportNARA Subscribed
Training programs designed to increase participation of underrepresented students in cancer-related careers rarely include structured community engagement components. We describe the design and pilot of the Field Experience in Cancer Outreach and Engagement (FECOE), a program developed as part of the CREATE Partnership (Cancer Research and Education to Advance HealTh Excellence), a National Cancer Institute-funded grant to San...
Age-specific climate sensitivity of respiratory hospitalizations in a tropical coastal city: 20-year Random Forest forecastsNARA Subscribed
Respiratory diseases remain a major public health challenge in tropical coastal cities, where persistent heat-humidity interactions and climate variability shape population vulnerability. This study quantified associations between atmospheric conditions and respiratory hospitalizations in Maceió, Brazil, using a 20-years time series (2000–2019). Weekly hospitalization rates stratified by age (children 0–4 years, adults 5–59 ye...
Mechanisms of dyspnoea and exercise intolerance in smokers with preserved ratio impaired spirometryNARA Subscribed
Purpose Smokers with preserved ratio impaired spirometry (PRISm) present reduced forced expiratory volume in the first second (FEV₁ < 80% predicted) but preserved FEV 1 /forced vital capacity (FVC) ≥ 0.7. Although they do not meet diagnostic criteria for chronic obstructive pulmonary disease (COPD), they often report respiratory symptoms and exercise intolerance. We aimed to compare sensory and physiological responses to exerc...
Improving wetland management through First Nations’ knowledge and a spatial visualisation toolNARA Subscribed
As wetlands continue to decline, there is an urgent need to improve their management by following the guidelines of international programs. The Ramsar Convention on Wetlands requires assessing baseline conditions and monitoring, for which Earth Observations are powerful tools. However, spatial and temporal limitations require integrated co-management, incorporating First Nations' Knowledge. We address three case studies with u...
The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Ethane is the most abundant non-methane hydrocarbon in Earth’s atmosphere and acts as an indirect greenhouse gas, influencing the atmospheric lifetime of methane. Therefore, understanding the development of trends and identifying trend reversals in atmospheric ethane is crucial. Ethane abundance is measured at different ground-based stations worldwide using Fourier transform infrared remote sensing techniques. We compile a new...