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Mechanisms of breast cancer dormancy in bone metastasisNARA Subscribed
Bone metastasis remains a serious threat to breast cancer patients. This condition arises from the outgrowth of previously dormant tumour cells in this site. Dormant tumour cells are almost impossible to detect in human patents, and these cells acquire “stem like” characteristics rendering them resistant to current cancer therapies. Furthermore, the development of therapies to target this population has proved challenging. The...
Ferric carboxymaltose (FCM) and ferric derisomaltose (FDI) are key for treating iron deficiency anemia. However, FCM has been shown to raise serum fibroblast growth factor (FGF)-23 levels, causing hypophosphatemia and alterations in bone turnover in some patients. To date, it is unknown if FCM and FDI also affect bone mineralization. This study examined FDI and FCM effects on bone mineralization and FGF-23 in healthy mice, avo...
IFSET special issue on 3D printingNARA Subscribed
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Urban earthworm communities driven more by climate and elevation than urbanisation intensityNARA Subscribed
Soil biodiversity, particularly earthworms, plays a crucial role in ecosystem functions and services but remains largely understudied in urban environments. In this context, we conducted a synthesis analysis of 41 studies from urban environments (726 records, 1995–2024) to (1) describe patterns of earthworm communities, (2) identify the main drivers shaping urban earthworm communities, focusing on the effects of climate, degre...
A hybrid framework to estimate live fuel moisture content through land surface modellingNARA Subscribed
Wildfires are among the most powerful natural phenomena that have severe environmental and social impacts. Their increasing frequency and intensity, driven by climate change and unsustainable land-use practices, emphasise the importance of reliable fire risk assessment tools. Live fuel moisture content (LFMC) is a key variable for wildfire risk assessment and management, as it directly influences fire behaviour and propagation...
Effects of Biodiversity Loss on Freshwater Ecosystem Functions Increase With the Number of StressorsNARA Subscribed
A multitude of anthropogenic stressors drive biodiversity loss and alter ecosystem functioning. Freshwaters, which contribute disproportionally to global biodiversity and biogeochemical cycles, are particularly threatened. Although the relationship between biodiversity and ecosystem functions (BEF) is generally well‐established, especially in terrestrial ecosystems, the role of multiple, co‐occurring stressors in modulating th...