Background Neuroinflammation involves the activation of glial cells, particularly astrocytes, and microglia, in response to pathological stimuli. Astrocyte activation is characterized by increased pro-inflammatory cytokines and oxidative stress. Given their role in neuroinflammation, targeting astrocytic mechanisms presents potential therapeutic opportunities. Ellagic acid (EA), a phenolic compound, exhibits antioxidant, anti-...

Background Recurrent pregnancy loss (RPL) is characterized by two or more pregnancy losses. Despite its etiology encompassing known risk factors, over half of the cases remain idiopathic. In this sense, the search for molecular and cellular mechanisms that could be related to this condition is essential for explaining, at least in part, these cases. Cellular senescence (CS) is a state of cell cycle arrest that is present durin...

This study aimed to characterize greenhouse gas (GHG) fluxes in different cocoa production systems and correlate them with soil quality attributes in the Atlantic Forest biome. The research was conducted in the experimental area of the Executive Commission of the Cocoa Farming Plan (CEPLAC) in Ilhéus, Bahia, Brazil. The land-use systems analyzed were full-sun cocoa with Fabaceae cover crops (CFs); full-sun cocoa with Urochloa...

Pimarane diterpenes represent a notable class of metabolites. Secondary metabolites sphaeropsidin A (SphA) and sphaeropsidin B (SphB), produced by phytopathogenic fungi, have been recently reported for their potential efficacy against bovine coronavirus (BCoV). Hence, for discovering natural antivirals to serve as alternatives to conventional drugs, in this study the efficacy of SphA and SphB during infection with canine coron...