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The involvement of TNFRSF25 in age-related hearing lossNARA Subscribed
Hearing loss is a prevalent sensory condition that affects the ability to perceive sounds. Hair cells play a vital role in hearing by converting mechanical sound vibrations into electrical signals that are transmitted to the brain. In humans, if damaged, these specialized sensory cells do not regenerate, leading to reduced sensitivity to sound, difficulty understanding speech, and deafness. The incidence of hearing loss increa...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Microorganisms are ubiquitous in nature, representing a significant portion of global biodiversity and playing vital roles in ecosystem functions, biogeochemical cycles, and organismal health. The growing recognition of microbial importance and their potential to address ecological and global challenges has inspired a renewed interest and innovation in microbial ecology. This field has benefited immensely from sequencing techn...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Sea urchin gonads (called uni) are highly valued in seafood markets, creating demand for sustainable production. In Seychelles, small-scale farming of Tripneustes gratilla is promising, but costly pelleted feeds for gonad enhancement limit feasibility. This study evaluated alternative fresh feeds, Sargassum spp., carrots (Daucus carota), moringa (Moringa oleifera), and a mixed diet, over 10 weeks using 200 T. gratilla (average...
Stable tropical conditions and a near-pristine marine environment in the Seychelles suggest a high potential for seaweed aquaculture to supply growing global markets for sustainable marine products. The aims of this study were to assess the mercury content in five seaweed species that are candidates for aquaculture in Seychelles: Gracilaria cortica, Gracilaria salicornia, Caulerpa racemosa, Sargassum spp., and Asparagopsis tax...
Purpose This paper aims to present the ISO 14075—Environmental management—Principles and framework for social life cycle assessment(S-LCA) which was developed by the Working Group 15 of ISO/TC 207/SC 5. In this study, we present the main discussion points, insights on the development process, differences in terminology with current literature, and mutual concessions leading to the compromises made. Methods A period of 3 years...
Investigating the feasibility and conditions for outdoor microalgae cultivation in SeychellesOA Marine
Microalgae play a critical role in aquaculture hatcheries as a primary feed source, supplying lipids, proteins, and vitamins to nearly all aquaculture species. Traditionally cultivated indoors under controlled conditions, microalgae production is resource intensive. This study examines the potential for outdoor microalgae farming in equatorial regions like Seychelles, utilizing abundant sunlight and stable high temperatures fo...