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Modulation of conformational features and oligomerization of MMACHC by cobalamin variants: impact of the R161Q mutation in cblC diseaseNARA Subscribed
Vitamin B12 (cobalamin, Cbl) is a coordination compound of the cobalt, located at the center of a corrin ring composed of four pyrrolic-like groups. The cobalt ion can be bound to a variety of upper axial ligands, which vary among different cobalamin forms, including hydroxocobalamin (OHCbl), cyanocobalamin (CNCbl), methylcobalamin (MeCbl), and adenosylcobalamin (AdoCbl). MeCbl and AdoCbl are considered the biologically active...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Genetic diversity of BoLA-DRB3 in Latin American Creole cattle: an update of the state of the artNARA Subscribed
Genetic diversity of the bovine leukocyte antigen BoLA-DRB3 gene has been reported in cattle breeds due to its central role in immune response. However, the gene has been characterized in only a few Latin American native cattle breeds. In this study, we aimed to investigate the genetic diversity of this gene in other native bovine breeds from Argentina, Bolivia, Cuba, and Paraguay, thereby contributing to the global knowledge...
Mind the Gaps: Shortfalls in Studies of the Intraspecific Genetic Diversity of Plants Across the Gran ChacoNARA Subscribed
Intraspecific genetic diversity (IGD) is a fundamental component of biodiversity, essential for understanding the evolutionary histories and demographic processes of species, and is key to effective conservation planning. However, ecologically important regions such as the Gran Chaco, South America's second‐largest forested biome, remain largely underexplored. Encompassing diverse vegetation across climatic and altitudinal gra...
Dipteran parasitoids as biocontrol agentsNARA Subscribed
Numerous studies conducted on a variety of temporal and spatial scales around the world show that dipteran parasitoids can exert effective control over some insect pests. This paper provides an overview of major examples of successful classical and augmentative biological control initiatives, organized by major dipteran families which include parasitoid species (i.e., Tachinidae, Phoridae, Sarcophagidae, Cryptochetidae, Bombyl...