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Immune dysregulation is central in bacterial sepsis with lipopolysaccharide (LPS) of gram-negative bacteria acting as a key component in innate immune activation. Modulation of the host response by potential immunomodulatory agents may confer benefits. This ex vivo study compared cytokine responses induced by E. coli and P. aeruginosa LPS and evaluated the impact of cefiderocol on LPS-induced immune activation in human whole b...
Gastrointestinal infections significantly impact sheep health and productivity, with diarrhea and parasites particularly threatening lambs. To address these challenges, feed additives offer solutions to enhance animal health and performance. This study aimed to investigate the effects of humic acids (HA) on the gastrointestinal tract and growth of lambs. Forty 1/2 Hampshire Down weaned lambs (aged 100.9 ± 7.1 days; average wei...
Whether the magnitude of individual cytokine, cellular, and clinical responses to the intravenous lipopolysaccharide (LPS) challenge is constant in individuals over extended time periods is unknown. Nine healthy volunteers received an intravenous LPS injection of 2 ng/kg bodyweight twice at intervals of at least one year. Circulating cytokines and leukocyte subsets were quantified using a multiplex immunoassay and cytometry by...
Atlantic-wide connectivity of Ascension Island green turtles revealed by finer-scale mitochondrial DNA markersNARA Subscribed
Marine turtles undertake long migrations across different geographies and habitats, exposing them to a wide range of threats throughout their lifespan. Analysing population structure and connectivity is key to informing effective conservation management. We expand knowledge of Atlantic-wide connectivity of green turtles ( Chelonia mydas ) by characterising the genetic structure of the Ascension Island nesting population, one o...
Plankton communities today and tomorrow—potential impacts of multiple global change drivers and marine heatwavesNARA Subscribed
In the context of global change, marine organisms are subjected not only to gradual changes in abiotic parameters, but also to an increasing number of extreme events, such as heatwaves. However, we still know little about the influence of heatwaves on the structure of marine communities, and experimental studies are needed to test the impact of heatwaves alone and in combination with other environmental drivers. Here, we condu...