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N-acetylcysteine mitigates oxidative stress and reduces alveolar bone damage on experimental periodontitis in ratsNARA Subscribed
This study evaluated the effect of N-acetylcysteine on oxidative biochemistry and bone damage during the development of ligature-induced experimental periodontitis in rats. The rats were divided into three groups (n = 8/group): control, experimental periodontitis (EP), or experimental periodontitis plus daily N-acetylcysteine administration (EP + NA) (100 mg/kg/day). Periodontitis was induced by bilateral silk ligatures on t...
Soil Microbial Diversity and Network Organization Respond to Land Use and Agricultural Inputs WorldwideNARA Subscribed
Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...
Introduction Small marine carnivores inhabiting fragmented rocky coastlines are increasingly exposed to anthropogenic pressures, yet mortality drivers in these systems remain poorly quantified. Methods We analyzed 22 years of carcass records (2003–2024) and standardized necropsies to evaluate the contribution of anthropogenic causes and their spatial and temporal patterns in marine otters ( Lontra felina ) from north-central C...
Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational InsightsNARA Subscribed
Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...
Aim To examine the species richness, distribution and macroecological patterns of elasmobranch assemblages across a broad latitudinal gradient in the Eastern Pacific Ocean (EPO). Location The study area encompasses the Pacific coast of the American continent, spanning from 65°N to 60°S, and extending from the coastline to approximately 1000 km offshore, encompassing the oceanic archipelagos. Taxon Elasmobranchs. Methods Utilis...