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Association mapping of hybrid seed set and heterosis in a central European multi-parental wheat populationNARA Subscribed
Key Message Heterosis in wheat results from a complex interplay of dominance and epistasis, with epistasis playing a major role, underscoring the genetic complexity and challenges in systematically exploiting hybrid vigor. Abstract The systematic exploitation of heterosis has the potential to increase wheat yields by around 10% compared to inbred lines. However, the lack of natural cross-pollination in wheat significantly incr...
Understanding habitat use and connectivity in estuarine fishes is essential for effective conservation and management. In this study, otolith microchemistry was applied to investigate habitat use and connectivity of the estuarine catfish Genidens genidens across three estuaries in southeastern Brazil. A total of 58 individuals were analyzed using laser ablation inductively coupled plasma mass spectrometry, focusing on strontiu...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Understanding the effectiveness of premating reproductive barriers in contact zones of closely related lineages is essential to assess risks to their long-term persistence. Here, we document the first contact zone with interspecific copulations between the Macaronesian mountain endemic Eurydema lundbladi and the widespread Palearctic E. ornata , located in mid-elevation habitats on La Palma Island, Canary Islands. Four intersp...
The Iberian killer whale subpopulation was assessed as critically endangered (CR) by the IUCN red list of threatened species based on the available information until 2011 on its low abundance, high newborn mortality, and dependency on the endangered Atlantic bluefin tuna. The present study focuses on updating the subpopulation demographic parameters between 2011 and 2023. Data were based on photo‐identification and stranding r...
Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...
Key message By combining data from different public and private breeding programs for genomic selection, we have increased the size and diversity of the training population, which has led to better predictions of grain yield and plant height in winter wheat compared to using individual training sets. Abstract The accuracy of genome-wide prediction is anticipated to improve with an increase in training population size. In our s...
Machine learning based mapping of physicochemical attributes in the Colombian Pacific seafloorNARA Subscribed
Seafloor mapping is a fundamental tool for sustainable use of hydrobiological resources, underwater research, and the management and conservation of oceans. Seafloor maps reveal a variety of biophysical features that enhance our understanding of ecological processes, facilitating monitoring, protection, and restoration actions. Seafloor mapping is expensive, hazardous, and complex, limiting its application especially in region...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Enriched Environment Contributes to the Recovery from Neurotoxin-Induced Parkinson’s Disease PathologyNARA Subscribed
Parkinson’s disease (PD) is a neurological disorder that affects dopaminergic neurons. The lack of understanding of the underlying molecular mechanisms of PD pathology makes treating it a challenge. Several pieces of evidence support the protective role of enriched environment (EE) and exercise on dopaminergic neurons. The specific aspect(s) of neuroprotection after exposure to EE have not been identified. Therefore, we have i...
Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) we...