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Springer Nature1
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European Journal of Clinical Pharmacology1
Publication Year
20251
Mario Rodenas-Rovira results 1 · Newest (Page 1/1, per page 25)
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Validation of pharmacokinetic model for quizartinib quantified by UPLC-MS/MS in patients with FLT3-ITD negative newly diagnosed acute myeloid leukemiaNARA Subscribed
European Journal of Clinical Pharmacology · 2025 · Vol. 81 · Issue 11 · Springer
Antonio Solana-Altabella; Carles Iniesta-Navalón; Maria Chovi-Trull; Rebeca Rodriguez-Veiga; Marina Lopez-Nogueroles; David Martínez-Cuadrón; Mayte Gil-Candel; Laura Torres-Miñana; Evelyn Acuña-Cruz; Isabel Cano-Ferri; Blanca Boluda; Irene Navarro-Vicente; Pilar Lloret-Madrid; Eva Barragán; Jose Vicente Gil; Mario Rodenas-Rovira; Juan Eduardo Megías-Vericat; Jorge Labrador; José Esteban Peris-Ribera; Jose Luis Poveda-Andrés; Pau Montesinos
Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...
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