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Regulatory Roles of Long Non-Coding RNAs in Methotrexate Pharmacology: Mechanistic and Translational InsightsNARA Subscribed
Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...
Aquaculture has been established as a sustainable alternative to traditional fisheries, which face challenges such as overexploitation and environmental degradation. However, disease outbreaks, often caused by poor farming conditions, pollution, and environmental stress, remain a major concern, leading to economic losses and increasing the risk of antibiotic resistance due to the overuse of antibiotics. Therefore, it is crucia...
In 2024, an expedition was conducted off northwestern Baja California, México, to find and identify the beaked whale species that produced the BW43 echolocation pulse previously recorded in this area and elsewhere in the North Pacific. There were five Mesoplodon sightings and 21 BW43 acoustic detections on both a towed array and drifting pole buoy recorders over the course of the survey. Three of the sightings had concurrent a...
Epilepsy is a chronic brain disorder characterized by abnormal and highly synchronous activity of neuronal cells. This condition is often associated with neuronal hyperexcitability and metabolic imbalances in regions such as the neocortex and archicortex (hippocampus). Pharmacological treatment with antiepileptic drugs has been essential in most cases. However, some patients continue to experience seizures despite medication....
Salmonid species have increasingly been established in South America for aquaculture and recreational fishing purposes. This study provides the first scientific record of the Chinook salmon ( Oncorhynchus tshawytscha ) in the Patos Lagoon (32°S), the world's largest choked coastal lagoon. The specimen was a female with 770 mm (total length), 3992.1 g, estimated age of 6 years and an advanced sexual maturation stage. Based on m...
The Atlantic goliath grouper ( Epinephelus itajara ) is the largest species of grouper in the Atlantic Ocean and is classified as critically endangered in Brazil. This study compared the isotopic ratios of carbon (δ 13 C) and nitrogen (δ 15 N) between the muscle tissue and dorsal‐fin rays of 37 juveniles to assess fin rays as a non‐lethal alternative to muscle tissue sampling. The δ 13 C values in rays were significantly highe...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...