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The phenotypic diversity between castes in social species has been associated with increased regulation of gene expression. while the regulatory role of transcription factors (TFs) in the social transitions of Hymenoptera (bees, ants and wasps) is well studied, it remains poorly explored in Blattodea (cockroaches and termites). By analysing three cockroach and five termite genomes, we show that while Blattodea share some conve...
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. This study investigates the genetic determinants of tobacco carcinogen metabolism among smokers, focusing on ancestry-informative markers (AIMs) near genes involved in metabolic activation (Phase I), detoxification (Phase II), and transport (Phase III) of tob...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Proximity to natural habitat is known to enhance pollination services in large‐scale agriculture, but it remains unclear whether this holds in tropical smallholder farms. These systems are embedded in ecologically complex landscapes, central to global food security, and depend heavily on biodiversity‐derived ecosystem services. We conducted a systematic review and meta‐analysis of 35 studies assessing the relationship between...
A photophysiological model of coral bleaching simulates declines and recovery during an emulated multi-doldrum marine heatwave eventNARA Subscribed
Mass coral bleaching events have become increasingly frequent since the 1980s as sea surface temperatures have risen. Extremes of light and temperature stress leading to coral bleaching can develop when doldrum meteorological conditions occur during a marine heatwave event. The coral bleaching model simulates bleaching by tracking the build-up of reactive oxygen species driven by temperature-mediated, light-driven oxidative st...
Environmental and Geographic Conditions on the Breeding Grounds Drive Bergmannian Clines in NightjarsNARA Subscribed
Aim To evaluate (1) whether three migratory nightjar species (Family Caprimulgidae) adhere to Bergmann's rule, (2) whether environmental factors on the breeding or wintering grounds determine body size, and (3) which mechanistic hypotheses best explain Bergmannian patterns in body size. Location North and South America; Europe and Africa. Taxon Eastern whip‐poor‐will ( Antrostomus vociferus ), Common nighthawk ( Chordeiles min...
Genetic variation and synonymous cultivars in the USDA lychee (Litchi chinensis Sonn.) collection assessed using genome-wide SNPsNARA Subscribed
Lychee ( Litchi chinensis ) fruits have high nutritional and pharmacological value, yet the crop is underutilized on global markets partly due to cultivation problems outside the native area and lack of knowledge/misidentification of cultivars. Using reduced representation sequencing, 78 trees representing 57 cultivars plus 13 trees without varietal names from the USDA lychee collection on Hawai’i were analysed. We aimed to (1...
An Overview of Vaccine Development Strategies for Columnaris‐Causing Bacteria in Cultured FishNARA Subscribed
Columnaris disease, caused by columnaris‐causing bacteria (CCB), affects cultured and wild freshwater fish worldwide. Belonging to the phylum Bacteroidota and the family Flavobacteriaceae, CCB are gram‐negative, yellow‐pigmented bacteria that are presumed ubiquitous in freshwater habitats. Since the first report of the disease in 1922, growth and survival, pathogenesis, and transmission of these pathogens have been intensely r...
What is science?NARA Subscribed
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
The basis for attribution assessments of current extreme weather and climatic events such as droughts and floods is that the record of such events is of sufficient length to be able to compare the occurrence and severity of recent events with those in the past. If this assumption holds, then the magnitude and frequency of extreme hydrological events in the current anthropogenically forced climate can be compared with those in...