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Marine Isotope Stage 4 glaciation in northern England, UK: Evidence from Victoria Cave, North YorkshireNARA Subscribed
Victoria Cave, north Yorkshire, England, contains a long sequence of Pleistocene clastic sediments and calcite flowstones. Earlier work, using U–Th dating, established that the flowstone units formed in interglacial stages corresponding to Marine Isotope Stages (MIS) 13, 11, 9, 7 and 5. The intervening laminated sediments were therefore assigned to glacial stages (MIS 12, 10, 6 and 2) and regarded as rhythmites that settled fr...
Diversity and functional group composition drive biogeographic patterns in marine biogenic structural complexityNARA Subscribed
Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Technical Considerations of Pharmacokinetic Assays for LNP-mRNA Drug Products by RT-qPCRNARA Subscribed
Lipid nanoparticle-messenger RNA (LNP-mRNA) drug products are a growing class of drug modalities. The unique composition of these drug products requires multiple measurements to account for the different components of these drug modalities. Pharmacokinetic (PK) measurements include measurement of the encapsulated mRNA and components of the LNP in circulation to understand the effectiveness of the therapeutic mRNA. The PK measu...
Less is more; intermediate oiling has a greater impact than heavy oiling on feather permeability in Northern Gannets (Morus bassanus)NARA Subscribed
Northern gannets are the largest migratory seabird in the Northern Atlantic and are vulnerable to oil pollution as a result of industrialisation spreading to marine environments. This study experimentally investigated the effect of crude oil on gannet feathers under laboratory conditions, with respect to (a) mass accumulation from contact with oil on water surface, and (b) water permeability of feathers following oiling. Ganne...
Bridging social and ecological science to create spatially explicit models of human-caused mortality of carnivoresNARA Subscribed
Research indicates that human-caused mortality (HCM) is a key factor limiting numerous large carnivore populations. However, efforts to represent HCM in spatially explicit models have generally been limited in scope—often relying on proxies, such as road or human density. Yet such efforts fail to distinguish different sources of HCM, which can arise from different antecedent processes. We offer a systems-based conceptual frame...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
The formation and failure of landslide dams is an important and understudied, multi-hazard topic. A framework of landslide dam formation susceptibility evaluation was designed for large-scale studies to avoid the traditional dependence on landslide volume calculations based on empirical relationships, which requires comprehensive local inventories of landslides and landslide dams. The framework combines logistic regression lan...