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Plankton are a key component in marine food webs and are vulnerable to climate-driven changes. Their phenology, distribution, and body size influence the biological carbon pump and higher trophic interactions. Plankton imaging enables high-frequency observations of community composition and size structure, but operational workflows for processing, validating and publishing large in situ image collections remain limited. This w...
Temporal transcriptomic profiling identifies core regulators in cytokine-induced gut barrier disruption in differentiated Caco-2 cellsNARA Subscribed
Objective The intestinal epithelial barrier maintains gut homeostasis, and its disruption contributes to inflammatory diseases such as Inflammatory Bowel Diseases (IBD). Although barrier restoration is a promising therapeutic strategy, most current approaches target immune responses rather than epithelial function. Since barrier injury and repair progress through discrete phases, this study aimed to define time-resolved epithe...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
With over half of people with HIV (PWH) in the U.S. entering older adulthood, identifying markers to distinguish Alzheimer’s disease (AD) and its precursor, amnestic mild cognitive impairment (aMCI), from other forms of neurocognitive impairment among PWH is urgent. We examined how HIV and aMCI status relate to AD CSF biomarkers in adult PWH and people without HIV (PWoH) characterized for aMCI. We included 80 PWH from the Nati...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Winners and losers in the host family over brood parasitismNARA Subscribed
Unprecedented Burning in Tropical Peatlands During the 20th Century Compared to the Previous Two MillenniaNARA Subscribed
Tropical peatland wildfire incidence has risen in recent decades, driven by drainage for land use and intensified by severe droughts with global climate change. These disturbances have altered vegetation structure, disrupted ecosystem functioning, and increased carbon emissions, particularly in Southeast Asia. However, the long‐term history and characteristics of wildfires in tropical peatlands remain largely unknown. Here, we...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Exploring the data demands and global opportunities for reconstructing morphological responses to climate changeNARA Subscribed
There is growing evidence that morphological change is a widespread response to the warming climate. The empirical basis for understanding this process has, to date, largely been correlative analyses of morphological time series. However, it is not clear what constitutes sufficient temporal sampling for assessing long-term morphological change. We analyzed two long-term high-quality morphological datasets, one including 33 spe...
The Black Array of Broadband Absolute Radiometers Earth Radiation Imager (BABAR-ERI) is a small, adaptable nadir-pointed pushbroom imager to measure Earth-leaving broadband radiance from 0.3 µm to 100 µm with higher information content than is currently measured by reducing radiometric uncertainty and enabling cloud-resolving spatial resolution. The three-instrument BABAR-ERI suite fits a 12U CubeSat form factor and contains c...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Heart disease is the leading cause of death globally. Although modern interventions have dramatically reduced the morbidity and mortality of heart disease, the lack of knowledge of key underlying mechanisms has limited the development of effective therapeutics. Pannexins encompass a group of three transmembrane channel-forming proteins best known for their role in purinergic signaling through the release of ATP. Pannexins, par...