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Resident Parasitoids and Biotic Resistance to Invasive Species in Hawaiʻi, and Implications for Biological Control ProgramsNARA Subscribed
Hawaiʻi is subject to disproportionately high rates of biological invasion, including adventive insects. These alien species have been the targets of numerous biological control efforts. The contribution of native species preventing adventives from becoming invasive has received little attention. We analyzed numbers of invasive species utilized by native parasitoids, showing that resident natural enemies infrequently attack al...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Effective management of deep-sea ecosystems and the high seas is hindered by the absence of a globally consistent framework for characterizing benthic habitats. Here we present the first global ecological classification of the seafloor, comprising 250 unique ecological benthic units (EBUs), distributed on the seafloor as nearly 700,000 EBU polygon occurrences, generated by intersecting a high-resolution geomorphic map with mul...
Your brain doesn’t look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-oldNARA Subscribed
The cognitively-intact oldest-old (85 +) may be the most-resilient members of their birth cohort; due to survivorship effects (e.g., depletion of susceptibles), risk factors associated with brain aging biomarkers in younger samples may not generalize to the cognitively-intact oldest-old. We evaluated associations between established aging-related risk factors and brain-predicted age difference (brainPAD) in a cross-sectional c...
Hydrogeology, European colonialism, local communities and First Peoples: moving beyond business as usualNARA Subscribed
European colonialism altered the connections between First Peoples, local communities, and groundwater systems across the world. In many countries, the practice of hydrogeology remains intertwined with the economic agendas of colonial settler communities, making colonialism a useful lens through which to consider our work. This paper briefly summarizes connections between First Peoples, local communities and groundwater, as we...
Validation of a novel multi-exercise approach to isometric resistance training in normotensive adultsNARA Subscribed
Purpose Short- to long-term isometric resistance training (IRT) can produce clinically meaningful reductions in resting blood pressure, but established methods are costly or require laboratory access. An affordable method could improve accessibility; however, there is a need to establish efficacy and safety prior to prescription as an alternative IRT method. This study aims to determine whether a novel isometric training band...