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Purpose The ocular lens capsule is a biomechanically specialized basement membrane essential for lens function, yet its regional micromechanical properties remain incompletely characterized. Methods We employed atomic force microscopy (AFM)-based force spectroscopy to map the stiffness of young porcine anterior and posterior lens capsule samples under physiologically hydrated conditions. A refined dissection protocol was used...
Multiple Nuclear Gene Phylogeny of Trichiuroidea (Teleostei, Acanthomorpha) Supports Recognition of the Family LepidocybiidaeNARA Subscribed
The Trichiuroidea, commonly known as snake mackerels and cutlassfishes, constitute an important component of marine pelagic and demersal fish assemblages. Members of this superfamily exhibit a wide spectrum of body shapes from fusiform to elongate and are currently classified into two families (Gempylidae and Trichiuridae), comprising 26 genera and 73 species. In this study, a new and comprehensive multiple nuclear gene datase...
The South-East Pacific (SEP) plays a key role in the global carbon cycle. However, despite its importance, its ability to absorb anthropogenic carbon dioxide (CO 2 ) remains poorly constrained due to strong variability and spatial heterogeneity in the air-sea carbon flux (FCO 2 ). Uncertainties persist regarding the contrasting responses of the northern upwelling system and of the southern fjord-dominated region, as well as th...
Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematologic malignancy patients and hematopoietic cell transplant (HCT) recipients. Mold cholecystitis has rarely been described. We present a case of disseminated Lomentospora prolificans , that had recrudescence of symptoms with acute cholecystitis. Treatment included a temporary cholecystostomy and administration of the novel antifungal f...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) is the leading cause of dementia and evidence suggests that alcohol, the most commonly used addictive substance, may increase AD risk. Locus coeruleus (LC) neurons are the primary source of norepinephrine in the brain and these neurons degenerate early in AD. In rodent models, lesioning the LC increases amyloid beta (Aβ) pathology suggesting that LC integrity and norepinephrine signaling obstruct Aβ pa...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
New Guinea, the most botanically diverse island on the planet, is the location for one of the boldest conservation initiatives. The Manokwari Declaration aims to achieve 70% conservation designation for the Bird's Head Peninsula. This is 40% higher than the 2022 Global Biodiversity Framework target. However, there is a lack of species occurrence data to support evidence of where biodiversity can be best protected. To address t...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...