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Rationale Negative affect plays a prominent role in the maintenance of alcohol use disorder (AUD) and has been identified as a risk factor for relapse to alcohol. To date, however, treatment options that target negative affective states and consecutive relapse risk in AUD are insufficient. Oxytocin (OXY) might be a promising approach for addressing negative affective states and resulting motivation to use alcohol. Objectives W...
Explosives released by dumped warfare material pose a threat to the marine environment and can enter the marine food web. 2,4,6-Trinitrotoluene (TNT) is one of the most used explosives in munitions and is, therefore, of special interest. To test the uptake, depuration, and potential biotransformation of TNT, common blue mussels ( Mytilus edulis ) from the German North Sea were exposed to different TNT concentrations in two lab...
Mobilization of Readily Exchangeable Organic P – A Potential Driver of Enhanced P Acquisition Efficiency in Upland RiceNARA Subscribed
High phosphorus (P) fixation in soils is a major constraint on crop production worldwide. To address this challenge, we investigated plant-induced changes in soil P pools, aiming to identify superior P uptake strategies by examining whether different upland rice genotypes access various P sources in the rhizosphere. Two genotypes (DJ123 and Nerica4) with varying P acquisition efficiencies (PAEs) were grown in an Andosol under...
The CoA thioester of 2‐(carboxymethyl)cyclohexane‐1‐carboxylic acid has been identified as a metabolite in anaerobic naphthalene degradation by the sulfate‐reducing culture N47. This study identified and characterised two acyl‐CoA dehydrogenases (ThnO/ThnT) and an intramolecular CoA‐transferase (ThnP) encoded within the substrate‐induced thn operon, which contains genes for anaerobic degradation of naphthalene. ThnP is a CoA t...
Fertilizer Addition Modifies Utilization of Different P Sources in Upland Rice on Strongly P-fixing AndosolsNARA Subscribed
Aims High Phosphorus (P) efficiencies such as internal P utilization efficiency (PUE) and P acquisition efficiency (PAE) are crucial for upland rice production, particularly on highly P-fixing soils like Andosols. While the effect of root traits associated with high PAE in upland rice has been studied intensively, less attention has been given to the origin of P (native soil-P versus fertilizer-P) taken up by plants when evalu...
Zusammenfassung Ziel dieser Arbeit ist die Beschreibung der Entwicklung einer webbasierten, interaktiven Darstellung von maximalen tolerierbaren Verzehrmengen für ausgewählte Lebensmittel, die beispielsweise in einer Ereignissituation als potenziell kontaminiert angenommen werden („Kontaminantenrechner“). Die vorliegende Arbeit beschreibt einen Katalog wissenschaftlicher Anwendungskriterien für einen solchen Kontaminantenrechn...
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na + channel (ENaC) play essential roles in transepithelial ion and fluid transport in numerous epithelial tissues. Inhibitors of both channels have been important tools for defining their physiological role in vitro. However, two commonly used CFTR inhibitors, CFTR inh -172 and GlyH-101, also inhibit non-CFTR anion channels, indica...
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparisonNARA Subscribed
Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible adverse effects, starting with a general cytotoxicity screening. The Horizon 2020 project “Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices (REFINE)” identified in vitro cyt...
Global maps of soil temperatureNARA Subscribed
Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1‐km 2 r...
In lichen symbioses, fungal secondary metabolites provide UV protection on which lichen algae such as trebouxiophycean green algae—the most prominent group of photobionts in lichen symbioses—sensitively depend. These metabolites differ in their UV absorbance capability and solvability, and thus vary in their propensity of being leached from the lichen body in humid and warm environments, with still unknown implications for the...
In orderto reduce the negative consequences of raw‐material extraction, it is necessary to accurately report raw‐material use and to understand its drivers in society. In this study, we conduct a multi‐regional environmentally extended input–output analysis of Germany's past raw‐material use. We then perform a two‐stage structural decomposition analysis (SDA) of the development of material use in order to identify the main dri...
Aluminium is one of the most abundant elements in earth’s crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs...
ATP ‐dependent/‐independent enzymatic ring reductions involved in the anaerobic catabolism of naphthaleneNARA Subscribed
Summary Polycyclic aromatic hydrocarbons are among the most hazardous environmental pollutants. However, in contrast to aerobic degradation, the respective degradation pathways in anaerobes are greatly unknown which has so far prohibited many environmental investigations. In this work, we studied the enzymatic dearomatization reactions involved in the degradation of the PAH model compounds naphthalene and 2‐methylnaphthalene i...