Michael Cheng results 210
· Newest (Page 1/9, per page 25)
Author: Michael Cheng ×Clear All Filters
Search Results
Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbationsNARA Subscribed
Acute respiratory exacerbations in bronchiectasis are important as they impair quality of life and are associated with accelerated lung function decline. Yet, no validated methods exist to identify children at increased risk of exacerbations. We therefore determined if peripheral blood gene expression (GE) signatures can identify those at risk of an impending exacerbation. Thirty-one children with bronchiectasis had RNA extrac...
Controversy and consensus: common ground and best practices for life cycle assessment of emerging technologiesNARA Subscribed
Public and private interest in life cycle assessment (LCA) has grown as environmental disclosure norms tighten, driving demand for decision-relevant assessment early in technological development cycles. Early-stage LCA has the potential to guide design choices, steer innovation, and mitigate lock-in of adverse environmental impacts. However, many aspects of early-stage LCA practice remain unsettled. We convened experts in a se...
Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findingsNARA Subscribed
Air pollution remains a significant global health challenge and is increasingly recognized as a critical exposomic risk factor for adverse birth outcomes. Although numerous epidemiological studies have linked prenatal air pollution exposure to low birth weight, preterm birth, and stillbirth, important uncertainties remain regarding the underlying biological mechanisms, critical exposure windows, and the interplay between diffe...
We herein constructed a phylogeny of Lepidoptera synthesizing multiple information types, a phylogenomics backbone, a multigene supermatrix with species‐comprehensive DNA barcodes, and topological information from a compiled database of standardized machine‐readable trees from over 100 previous studies. We then applied the new phylogenetic synthesis as a profiling framework for a large DNA barcode dataset of caterpillars from...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Genome‐wide associations of leaf spectral variation in MAGIC lines of Nicotiana attenuataNARA Subscribed
The application of in‐field and aerial spectroscopy to assess functional and phylogenetic variation in plants has led to novel ecological insights and supports global assessments of plant biodiversity. Understanding how plant genetic variation influences reflectance spectra will help harness this potential for biodiversity monitoring and improve understanding of why plants differ in functional responses to environmental change...
Purpose The Advanced Integrated Respiratory (AIR) model was developed as a physiologically relevant benchtop system designed to assess aerosol deposition and interactions within the respiratory tract. Methods This model integrates a three-dimensional (3D) cast of the human airways with a vacuum driven aerosol inhalation flow and an air liquid interface (ALI) cell culture platform. In this study, the integrated AIR and ALI cell...
Purpose In vitro respiratory models such as the Next Generation Impactor (NGI), remain the gold standard for aerodynamic particle size distribution (APSD) testing, however, they lack the anatomical complexity, limiting their ability to replicate in vivo deposition. To address this limitation, the Advanced Integrated Respiratory (AIR) model, a physiologically relevant benchtop system incorporating anatomically accurate silicone...
Physical monitoring of an erosional hotspot on a nourished beach: a case study of Ortley Beach, New JerseyNARA Subscribed
Beaches worldwide play an essential role in shore protection under storm conditions. How to identify the threshold beach width for effective shore protection remains largely unresolved due to a scarcity of measured beach profiles with sufficient temporal and spatial resolutions. In this study, weekly to monthly surveys spaced 100 m along the shoreline have been conducted at Ortley Beach, New Jersey since Fall 2023. The survey...