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Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in BrazilNARA Subscribed
Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...
Multi-fidelity data-driven approach to operational guidanceNARA Subscribed
Mixed Support for Pleistocene Sea‐Level Fluctuations in Promoting the Diversification of Anole Lizards in the Northern Lesser AntillesNARA Subscribed
In the Pleistocene, climatic changes resulted in cycles of sea‐level fluctuation that periodically fragmented islands into aggregate island complexes. These temporary saltwater barriers between islands within an island bank had the potential to decrease migration between populations on separate islands, resulting in increased genetic divergence and potentially speciation. In the Lesser Antilles, Anolis lizards (anoles) are dis...
Surveying the scene: A review of how landscapes are valuedNARA Subscribed
The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...
Evaluation of siRNA-mediated knockdown of heat shock protein 16.2 in adult Acropora cervicornisOA Marine
Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult cor...
Lake sturgeon ( Acipenser fulvescens ) growth and longevity estimated from adult capture–mark–recapture dataNARA Subscribed
Effective fishery management policy depends on accurate life‐history data, particularly for harvested species. Longevity is a core life‐history trait that is directly related to annual survival and lifetime reproductive potential, but fish longevity is generally not well documented, particularly for long‐lived species. We used capture–mark–recapture data spanning 44 years as an alternative method to estimate sex‐specific adult...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Regional Nasal Drug Deposition in Pediatric vs. Adult Models: In vitro Insights into User Technique and Breathing Patterns SensitivityNARA Subscribed
Purpose Although in vitro studies recommended for establishing bioequivalence of locally acting nasal suspension products provide useful information regarding product performance, currently they are not designed to fully account for variability introduced by patient-specific factors such as administration technique and breathing patterns. This limitation, combined with ethical and practical challenges in conducting pediatric c...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Connectivity is a multifaceted concept that has important implications for the management and conservation of marine and freshwater fishes. We developed a conceptual framework that encompasses multiple, interrelated categories of connectedness, including landscape (e.g., structural, functional) connectivity and ecological (e.g., trophic, genetic, demographic) connectivity, that together shape the flow of organisms, energy and...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...